TY - JOUR
T1 - Changes in patterns of practice for prostate cancer radiotherapy in Italy 1995-2003. A survey of the Prostate Cancer Study Group of the Italian Radiation Oncology Society
AU - Pegurri, Ludovica
AU - Buglione, Michela
AU - Girelli, Giovanni
AU - Guarnieri, Alessia
AU - Meattini, Icro
AU - Ricardi, Umberto
AU - Mangoni, Monica
AU - Gabriele, Pietro
AU - Bellavita, Rita
AU - Krengli, Marco
AU - Bonetta, Alberto
AU - Cagna, Emanuela
AU - Bunkheila, Feisal
AU - Borghesi, Simona
AU - Signor, Marco
AU - Di Marco, Adriano
AU - Bertoni, Filippo
AU - Stefanacci, Marco
AU - Gatta, Roberto
AU - De Bari, Berardino
AU - Magrini, Stefano Maria
PY - 2014
Y1 - 2014
N2 - Aims and background. In 2002, a survey including 1759 patients treated from 1980 to 1998 established a "benchmark" Italian data source for prostate cancer radiotherapy. This report updates the previous one. Methods. Data on clinical management and outcomes of 3001 patients treated in 15 centers from 1999 through 2003 were analyzed and compared with those of the previous survey. Results. Significant differences in clinical management (-10% had abdominal ma gnetic resonance imaging; +26% received ≥70 Gy, +48% conformal radiotherapy, -20% pelvic radiotherapy) and in G3-4 toxicity rates (-3.8%) were recorded. Actuarial 5- year overall, disease-specific, clinical relapse-free, and biochemical relapse-free survival rates were 88%, 96%, 96% and 88%, respectively. At multivariate analysis, D'Amico risk categories significantly impacted on all the outcomes; higher radiotherapy doses were significantly related with better overall survival rates, and a similar trend was evident for disease-specific and biochemical relapse-free survival; cumulative probability of 5-year late G1-4 toxicity was 24.8% and was significantly related to higher radiotherapy doses (P
AB - Aims and background. In 2002, a survey including 1759 patients treated from 1980 to 1998 established a "benchmark" Italian data source for prostate cancer radiotherapy. This report updates the previous one. Methods. Data on clinical management and outcomes of 3001 patients treated in 15 centers from 1999 through 2003 were analyzed and compared with those of the previous survey. Results. Significant differences in clinical management (-10% had abdominal ma gnetic resonance imaging; +26% received ≥70 Gy, +48% conformal radiotherapy, -20% pelvic radiotherapy) and in G3-4 toxicity rates (-3.8%) were recorded. Actuarial 5- year overall, disease-specific, clinical relapse-free, and biochemical relapse-free survival rates were 88%, 96%, 96% and 88%, respectively. At multivariate analysis, D'Amico risk categories significantly impacted on all the outcomes; higher radiotherapy doses were significantly related with better overall survival rates, and a similar trend was evident for disease-specific and biochemical relapse-free survival; cumulative probability of 5-year late G1-4 toxicity was 24.8% and was significantly related to higher radiotherapy doses (P
KW - Patterns of practice
KW - Pro-state cancer
KW - Radiotherapy
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M3 - Article
C2 - 24675488
AN - SCOPUS:84894229015
VL - 100
SP - 31
EP - 37
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 1
ER -