Changes in patterns of uveitis at a tertiary referral center in Northern Italy: analysis of 990 consecutive cases

Cimino Luca, Aldigeri Raffaella, Marchi Sylvia, Mastrofilippo Valentina, Viscogliosi Fabiana, Coassin Marco, Soldani Annamaria, Savoldi Luisa, De Fanti Alessandro, Belloni Lucia, Zerbini Alessandro, Parmeggiani Maria, Chersich Matthew, Soriano Alessandra, Salvarani Carlo, Fontana Luigi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The role of uveitis, an uncommon ocular disease, is often neglected in research and treatment of autoimmune conditions. The study described the spectrum of uveitis at a referral center in North Italy, and compared that to a previously published series of patients. Methods: We reviewed all patients with uveitis diagnosed from 2013 to 2015 at the Immunology Eye Unit, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy. We examined patient characteristics, disease spectrum, and etiologies. Results: In total, 990 cases of uveitis were identified, who were mostly female (59%) with a median age at presentation of 44 years (interquartile range = 29–57). Anterior uveitis was most frequent (53.5%), followed by panuveitis (22.8%), posterior (16.2%), and intermediate uveitis (5.5%). Anterior herpetic uveitis (15.6%), Fuchs uveitis (9.7%), and HLA-B27 positive anterior uveitis (7.7%) were the most common specific diagnoses. Compared with the previous series, we observed an increased incidence of uveitis, and a different pattern of diagnoses. Rates of herpetic, HLA-B27 positive uveitis, and presumed ocular tuberculosis were higher, but Fuchs uveitis was less frequent. Conclusions: The pattern of uveitis appears to be changing, very likely due to population-level increases in infectious diseases, to the availability of new diagnostic tests and to the interdisciplinary approach used in patient diagnosis.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalInternational Ophthalmology
DOIs
Publication statusAccepted/In press - Jan 9 2017
Externally publishedYes

Keywords

  • Epidemiology
  • Infection
  • Interdisciplinary approach
  • Italy
  • Systemic disease
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology

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