Changes in plasma atrial natriuretic peptide levels after a single sublingual dose of nifedipine in hypertensive patients

A. Rappelli, P. Dessi-Fulgheri, F. Bandiera, G. Di Noto

Research output: Contribution to journalArticle

Abstract

To see whether the acute natriuretic effect of nifedipine (NIF) is accompained by changes in atrial natriuretic peptide (ANP) levels, a group of eight hypertensive patients were studied. After at least a week of constant sodium intake, placebo (P) or NIF (10 mg s.l.) were administered and blood pressure (BP), heart rate (HR),plasma renin activity (PRA), plasma adolesterone (PA) and ANP plasma levels, urinary sodium, urinary volume and creatinine clearance were monitored for 2 hours. While P did not induce changes in any of the above parameters, NIF administration was followed by a significant decrease in BP and an increase in urinary sodium, urinary volume and creatinine clearnace; these changes were accompained by a significant rise in ANP levels from 19.4 ± 2.8 pg/ml to a maximum of 23.9 ± 2.5 pg/ml and 24.1 ± 2.2 pg/ml (p

Original languageEnglish
Pages (from-to)1503-1504
Number of pages2
JournalMedical Science Research
Volume15
Issue number24
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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