Changes in plasma levels of ghrelin, leptin, and other hormonal and metabolic parameters following standardized breakfast, lunch, and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents

A. E. Rigamonti, F. Agosti, A. De Col, N. Marazzi, C. L. Lafortuna, S. G. Cella, E. E. Muller, A. Sartorio

Research output: Contribution to journalArticle


Objective: To investigate in severely obese ado lescents the effects of a 3-week multidisciplinary weight-reduction intervention involving moderate energy restriction, individualised physical activity and behavior therapy on the response of some hormonal and metabolic parameters to meals and exercise. Design: Clinical longitudinal study on inpatients in a specialised institution. Subjects: A total of 20 obese adolescents (10 boys and 10 girls) aged 12-17 yr [body mass index (BMI): 37.7±6.1 kg/m2; fat mass (FM): 44.8±13.2 kg]. Measurements: The changes in plasma concentration of leptin, ghrelin, GH, IGF-I, insulin, glucose, and non-esterified fatty acids (NEFA) in response to standardised meals and exercise bouts were measured before and after the weight-reduction intervention. At the same times, body composition was assessed by bioelectrical impedance as well as appetite sensations using a visual analog scale. Results: At the end of the intervention, the adolescents had lost body weight and FM (expressed both in kg and %) (p

Original languageEnglish
Pages (from-to)633-639
Number of pages7
JournalJournal of Endocrinological Investigation
Issue number9
Publication statusPublished - Oct 2010



  • Adolescent
  • Ghrelin
  • Leptin
  • Obesity
  • Weight loss

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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