Levels of urokinase-type plasminogen activator antigen (uPA) were determined in plasma of patients with benign and malignant prostatic tumours. Plasma levels of uPA evaluated at T1 (before surgical procedure) and at T2 (after surgical removal of tumour) were, respectively, for cancer and for adenoma: 0.66 ± 0.22 ng/ml vs 0.25 ± 0.13 ng/ml (p <0.01) and 0.22 ± 0.09 ng/ml vs 0.23 ± 0.11 ng/ml (the difference was statistically non significant). When levels of uPA in patients with prostatic tumours were compared to plasma uPA in normal blood donors, only cancer patients at T1 had higher levels of uPA. These results suggest that elevated plasma levels of uPA could be a non-specific marker related to the presence of malignant prostate tissue.
|Translated title of the contribution||Changes in plasma urokinase levels in patients with neoplasia of the prostate|
|Number of pages||2|
|Journal||Acta Urologica Italica|
|Issue number||SUPPL. 2|
|Publication status||Published - 1993|
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