Abstract
Plasma concentrations of primidone and its metabolite phenobarbitone were monitored in 9 pregnant epileptic patients treated with primidone (and in 3 cases other antiepileptic drugs) given at constant doses throughout pregnancy and the Puerperium. Phenobarbitone plasma concentrations were monitored in another 6 patients given phenobarbitone itself. A trend towards increasing primidone plasma concentrations during the second quarter of pregnancy was evident in all patients, with a concomitant significant decrease in primidone-derived phenobarbitone plasma concentrations. A trend towards a lowering of plasma concentrations of phenobarbitone administered as such was confirmed. These results suggest the usefulness of a careful monitoring of primidone and primidone-derived phenobarbitone during pregnancy and the Puerperium. Discrepancies of findings with primidone and phenobarbitone are discussed in view of the possible mechanism involved.
Original language | English |
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Pages (from-to) | 252-260 |
Number of pages | 9 |
Journal | Clinical Pharmacokinetics |
Volume | 9 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1984 |
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)