The present study deals with the developmental profile of cytosolic and membrane-bound gangliosides in rabbit whole brain from the 21st day of pregnancy, the time at which brain could be macroscopically recognized and handled, till birth. In this period of prenatal life the content of membrane-bound gangliosides showed a 2.5-fold increase, referred to fresh and dry brain weight and to membrane-bound protein; the content of cytosolic gangliosides reached a maximum at 21-22 days of pregnancy, and then underwent at birth a threefold diminution. The qualitative pattern of membrane-bound gangliosides, in the same period of life, was characterized by an increase of G[D1a] and G[M1] (more marked for G[D1a], a decrease of G[T1a], and G[Q1b], and a constant level of G[D3] and G[D1b]. At 21 days of pregnancy the most abundant gangliosides were G[T1b] and G[Q1b], followed by G[D1a] and G[D1b]; at birth it was G[D1a], followed by G[T1b], G[D1b] and G[M1]. The qualitative pattern of cytosolic gangliosides closely resembled, during the entire period of prenatal life examined, that of membrane-bound gangliosides.
|Number of pages||6|
|Journal||Journal of Neurochemistry|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience