Changes in respiratory mechanics at birth in preterm infants: A pilot study

Chiara Veneroni, Domenica Mercadante, Anna Lavizzari, Mariarosa Colnaghi, Fabio Mosca, Raffaele L. Dellacà

Research output: Contribution to journalArticle

Abstract

Objective: We aimed to measure lung mechanics at birth by the forced oscillation technique (FOT) for assessment of the initial degree of lung aeration and the short-term aeration changes after applying different respiratory support strategies. Methods: Eighteen preterm infants (gestational age = 29-36 week) were randomized to receive either continuous positive airway pressure (CPAP) at 5 cmH2O only or combined with a sustained inflation (SI; 15 seconds at 25 cmH2O after 5 seconds of CPAP) at birth. We assessed the respiratory system reactance at 5 Hz (X5; increases with lung volume recruitment at a given distending pressure) at 2, 40, and 150 seconds after initiation of CPAP. k-Means clustering of the initial X5 value (X5,i) stratified newborn into either infants with lower (lowerX5,i; X5 < −280 cmH2O*s/L) and higher (higherX5,i; X5 > −240 cmH2O*s/L) initial degree of lung volume recruitment. Results: Initial values were highly heterogeneous. In the LowerX5,i group, X5 increased with time, with SI-patients showing significantly higher values at 150 seconds than the non-SI group (X5 = −89 ± 27 cmH2O vs −274 ± 58 cmH2O). In the higherX5,i group, X5 did not improve with time, regardless of the respiratory strategy, suggesting a lack of lung recruitment. Moreover, 75% of infants receiving SI in the higherX5,i group experienced a transient loss of aeration after the maneuver. Conclusions: Preterm newborns present initially with highly heterogeneous lung aeration at birth that significantly impacts the effectiveness of the subsequent lung volume recruitment strategy. FOT may represent a valuable tool for individualizing a respiratory resuscitation at birth as it is noninvasive and may be applied simultaneously to respiratory support.

Original languageEnglish
JournalPediatric Pulmonology
DOIs
Publication statusAccepted/In press - Jan 1 2020

Keywords

  • aeration at birth
  • force oscillation technique
  • newborns
  • recruitment maneuver
  • sustained inflation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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