Changes in serum lipids and blood glucose in non diabetic patients with metabolic syndrome after mixed meals of different composition

Adriana Branchi, Adriana Torri, Cristina Berra, Emanuela Colombo, Domenico Sommariva

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aims. To investigate the postprandial changes in serum lipoproteins and blood glucose and to verify whether different nutrient composition of the meal elicits different response in patients with (MetS+) and without (MetS-) metabolic syndrome. Research Design and Methods. 50 MetS+ patients and 50 age- and sex-matched MetS- consumed a regular lunch chosen among those more similar to their usual diet. Blood was drawn in the morning after 12-hour fasting and 2 and 4:30 hours after the meal. Results. Serum triglycerides increased more in MetS+ (35%, 4:30 hours after the meal) than in MetS- (29%), HDL-cholesterol decreased 2 hours after the meal in both groups (-4% and -5%, resp.). Blood sugar similarly increased in both groups (19%, 2 hours after the meal in MetS+ and 17% in MetS-) and plasma insulin increased more and remained high longer in MetS+ (73.5 and 52.3 U/mL, 2 and 4:30 hours after the meal) than in MetS- (46.7 and 21.6 U/mL). Difference in nutrient composition of the meal (carbohydrate 57%, fat 28% versus carbohydrate 45%, fat 35%) was not associated with differences in postprandial levels of triglycerides, HDL-cholesterol, glucose, and insulin within each group. Conclusions. As compared with MetS-, MetS+ patients show a greater hypertriglyceridemic and hyperinsulinemic response to a regular lunch whatever the carbohydrate or fat content of the meal.

Original languageEnglish
Article number215052
JournalJournal of Nutrition and Metabolism
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

metabolic syndrome
meals (menu)
blood lipids
blood glucose
Meals
Blood Glucose
Lipids
Serum
Lunch
lunch
Fats
Carbohydrates
blood serum
high density lipoprotein cholesterol
HDL Cholesterol
Triglycerides
nutrient content
insulin
triacylglycerols
Insulin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Food Science
  • Nutrition and Dietetics

Cite this

Changes in serum lipids and blood glucose in non diabetic patients with metabolic syndrome after mixed meals of different composition. / Branchi, Adriana; Torri, Adriana; Berra, Cristina; Colombo, Emanuela; Sommariva, Domenico.

In: Journal of Nutrition and Metabolism, Vol. 2012, 215052, 2012.

Research output: Contribution to journalArticle

@article{d5a5fc08337b4db182c2534a19a90bc6,
title = "Changes in serum lipids and blood glucose in non diabetic patients with metabolic syndrome after mixed meals of different composition",
abstract = "Aims. To investigate the postprandial changes in serum lipoproteins and blood glucose and to verify whether different nutrient composition of the meal elicits different response in patients with (MetS+) and without (MetS-) metabolic syndrome. Research Design and Methods. 50 MetS+ patients and 50 age- and sex-matched MetS- consumed a regular lunch chosen among those more similar to their usual diet. Blood was drawn in the morning after 12-hour fasting and 2 and 4:30 hours after the meal. Results. Serum triglycerides increased more in MetS+ (35{\%}, 4:30 hours after the meal) than in MetS- (29{\%}), HDL-cholesterol decreased 2 hours after the meal in both groups (-4{\%} and -5{\%}, resp.). Blood sugar similarly increased in both groups (19{\%}, 2 hours after the meal in MetS+ and 17{\%} in MetS-) and plasma insulin increased more and remained high longer in MetS+ (73.5 and 52.3 U/mL, 2 and 4:30 hours after the meal) than in MetS- (46.7 and 21.6 U/mL). Difference in nutrient composition of the meal (carbohydrate 57{\%}, fat 28{\%} versus carbohydrate 45{\%}, fat 35{\%}) was not associated with differences in postprandial levels of triglycerides, HDL-cholesterol, glucose, and insulin within each group. Conclusions. As compared with MetS-, MetS+ patients show a greater hypertriglyceridemic and hyperinsulinemic response to a regular lunch whatever the carbohydrate or fat content of the meal.",
author = "Adriana Branchi and Adriana Torri and Cristina Berra and Emanuela Colombo and Domenico Sommariva",
year = "2012",
doi = "10.1155/2012/215052",
language = "English",
volume = "2012",
journal = "Journal of Nutrition and Metabolism",
issn = "2090-0724",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Changes in serum lipids and blood glucose in non diabetic patients with metabolic syndrome after mixed meals of different composition

AU - Branchi, Adriana

AU - Torri, Adriana

AU - Berra, Cristina

AU - Colombo, Emanuela

AU - Sommariva, Domenico

PY - 2012

Y1 - 2012

N2 - Aims. To investigate the postprandial changes in serum lipoproteins and blood glucose and to verify whether different nutrient composition of the meal elicits different response in patients with (MetS+) and without (MetS-) metabolic syndrome. Research Design and Methods. 50 MetS+ patients and 50 age- and sex-matched MetS- consumed a regular lunch chosen among those more similar to their usual diet. Blood was drawn in the morning after 12-hour fasting and 2 and 4:30 hours after the meal. Results. Serum triglycerides increased more in MetS+ (35%, 4:30 hours after the meal) than in MetS- (29%), HDL-cholesterol decreased 2 hours after the meal in both groups (-4% and -5%, resp.). Blood sugar similarly increased in both groups (19%, 2 hours after the meal in MetS+ and 17% in MetS-) and plasma insulin increased more and remained high longer in MetS+ (73.5 and 52.3 U/mL, 2 and 4:30 hours after the meal) than in MetS- (46.7 and 21.6 U/mL). Difference in nutrient composition of the meal (carbohydrate 57%, fat 28% versus carbohydrate 45%, fat 35%) was not associated with differences in postprandial levels of triglycerides, HDL-cholesterol, glucose, and insulin within each group. Conclusions. As compared with MetS-, MetS+ patients show a greater hypertriglyceridemic and hyperinsulinemic response to a regular lunch whatever the carbohydrate or fat content of the meal.

AB - Aims. To investigate the postprandial changes in serum lipoproteins and blood glucose and to verify whether different nutrient composition of the meal elicits different response in patients with (MetS+) and without (MetS-) metabolic syndrome. Research Design and Methods. 50 MetS+ patients and 50 age- and sex-matched MetS- consumed a regular lunch chosen among those more similar to their usual diet. Blood was drawn in the morning after 12-hour fasting and 2 and 4:30 hours after the meal. Results. Serum triglycerides increased more in MetS+ (35%, 4:30 hours after the meal) than in MetS- (29%), HDL-cholesterol decreased 2 hours after the meal in both groups (-4% and -5%, resp.). Blood sugar similarly increased in both groups (19%, 2 hours after the meal in MetS+ and 17% in MetS-) and plasma insulin increased more and remained high longer in MetS+ (73.5 and 52.3 U/mL, 2 and 4:30 hours after the meal) than in MetS- (46.7 and 21.6 U/mL). Difference in nutrient composition of the meal (carbohydrate 57%, fat 28% versus carbohydrate 45%, fat 35%) was not associated with differences in postprandial levels of triglycerides, HDL-cholesterol, glucose, and insulin within each group. Conclusions. As compared with MetS-, MetS+ patients show a greater hypertriglyceridemic and hyperinsulinemic response to a regular lunch whatever the carbohydrate or fat content of the meal.

UR - http://www.scopus.com/inward/record.url?scp=84868689505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868689505&partnerID=8YFLogxK

U2 - 10.1155/2012/215052

DO - 10.1155/2012/215052

M3 - Article

C2 - 22474578

AN - SCOPUS:84868689505

VL - 2012

JO - Journal of Nutrition and Metabolism

JF - Journal of Nutrition and Metabolism

SN - 2090-0724

M1 - 215052

ER -