Changes in serum markers indicative of health effects in vineyard workers following exposure to the fungicide mancozeb: An Italian study

Claudio Colosio, Silvia Fustinoni, Emanuela Corsini, Cristina Bosetti, Sarah Birindelli, Daisy Boers, Laura Campo, Carlo La Vecchia, Jyrki Liesivuori, Sirpa Pennanen, Tatjana Vergieva, Ludovic G P M Van Amelsvoort, Peter Steerenberg, Gerard M H Swaen, Christo Zaikov, Henk Van Lveren

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of this study was to investigate the health effects induced by exposure to the fungicide mancozeb in Italian vineyard workers. Ninety-three Italian subjects entered the study - 48 vine-growers intermittently exposed to mancozeb and 45 healthy controls. The subjects were investigated three times: before the seasonal application of pesticides (T0), 30 days after the beginning of the application period (T30), and 45 days after T0 (T45). At T0 the comparison between agricultural workers and controls showed a higher prevalence of cold or flu symptoms, a statistically significant lower percentage of monocytes, higher absolute count of T lymphocytes, CD4 and natural killer cells, and lower plasma levels of IgA and IgM in workers. Such differences were not confirmed at T30 and T45. In fact at T30 in exposed workers, besides a significant increase of urinary ethylenethiourea, confirming mancozeb exposure, T lymphocytes, CD4 and natural killer cells, IgA and IgM returned to values comparable to those observed in controls. Moreover, no other differences in clinical signs, haematological, and immune parameters, such as the immune functional capability evaluated as a response to hepatitis B vaccination, was observed. Altogether the differences between exposed and controls were not consistently correlated to any clinical impairment and suggest that the seasonal application of mancozeb does not pose a significant health risk to exposed subjects.

Original languageEnglish
Pages (from-to)574-588
Number of pages15
JournalBiomarkers
Volume12
Issue number6
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Fungicides
Biomarkers
Health
T-cells
Natural Killer Cells
Immunoglobulin A
Immunoglobulin M
Ethylenethiourea
T-Lymphocytes
Health risks
CD4 Lymphocyte Count
Hepatitis B
Pesticides
Monocytes
Vaccination
Plasmas
mancozeb
Farms

Keywords

  • Ethylenebisdithiocarbamate fungicides (EBDCs)
  • Humans
  • Immunotoxicty
  • Mancozeb

ASJC Scopus subject areas

  • Biotechnology
  • Toxicology

Cite this

Changes in serum markers indicative of health effects in vineyard workers following exposure to the fungicide mancozeb : An Italian study. / Colosio, Claudio; Fustinoni, Silvia; Corsini, Emanuela; Bosetti, Cristina; Birindelli, Sarah; Boers, Daisy; Campo, Laura; La Vecchia, Carlo; Liesivuori, Jyrki; Pennanen, Sirpa; Vergieva, Tatjana; Van Amelsvoort, Ludovic G P M; Steerenberg, Peter; Swaen, Gerard M H; Zaikov, Christo; Van Lveren, Henk.

In: Biomarkers, Vol. 12, No. 6, 11.2007, p. 574-588.

Research output: Contribution to journalArticle

Colosio, C, Fustinoni, S, Corsini, E, Bosetti, C, Birindelli, S, Boers, D, Campo, L, La Vecchia, C, Liesivuori, J, Pennanen, S, Vergieva, T, Van Amelsvoort, LGPM, Steerenberg, P, Swaen, GMH, Zaikov, C & Van Lveren, H 2007, 'Changes in serum markers indicative of health effects in vineyard workers following exposure to the fungicide mancozeb: An Italian study', Biomarkers, vol. 12, no. 6, pp. 574-588. https://doi.org/10.1080/13547500701441315
Colosio, Claudio ; Fustinoni, Silvia ; Corsini, Emanuela ; Bosetti, Cristina ; Birindelli, Sarah ; Boers, Daisy ; Campo, Laura ; La Vecchia, Carlo ; Liesivuori, Jyrki ; Pennanen, Sirpa ; Vergieva, Tatjana ; Van Amelsvoort, Ludovic G P M ; Steerenberg, Peter ; Swaen, Gerard M H ; Zaikov, Christo ; Van Lveren, Henk. / Changes in serum markers indicative of health effects in vineyard workers following exposure to the fungicide mancozeb : An Italian study. In: Biomarkers. 2007 ; Vol. 12, No. 6. pp. 574-588.
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