TY - JOUR
T1 - Changes in skeletal muscle histology and metabolism in patients undergoing exercise deconditioning
T2 - Effect of propionyl-L-carnitine
AU - Brevetti, Gregorio
AU - Fanin, Marina
AU - De Amicis, Vincenzo
AU - Carrozzo, Rosalba
AU - Lello, Francesco D I
AU - Marione, Vincenzo Domenico
AU - Angelini, Corrado
PY - 1997
Y1 - 1997
N2 - To define the skeletal muscle abnormalities in patients undergoing exercise deconditioning and evaluate the metabolic effect of propionyl-L- carnitine (PLC), muscle biopsies were obtained from 28 patients with effort angina and 31 control subjects. Coronary artery disease patients received either placebo (n = 12), PLC (1.5 g IV followed by infusion of 1 mg/kg/min for 30 min, n = 10), or L-carnitine (1 g IV followed by infusion of 0.65 mg/kg/min for 30 min, n = 6) for 2 days. Exercise deconditioned patients treated with placebo showed normal muscle content of total carnitine and glycogen, and decrease in percentage of type 1 fibers (P
AB - To define the skeletal muscle abnormalities in patients undergoing exercise deconditioning and evaluate the metabolic effect of propionyl-L- carnitine (PLC), muscle biopsies were obtained from 28 patients with effort angina and 31 control subjects. Coronary artery disease patients received either placebo (n = 12), PLC (1.5 g IV followed by infusion of 1 mg/kg/min for 30 min, n = 10), or L-carnitine (1 g IV followed by infusion of 0.65 mg/kg/min for 30 min, n = 6) for 2 days. Exercise deconditioned patients treated with placebo showed normal muscle content of total carnitine and glycogen, and decrease in percentage of type 1 fibers (P
KW - Coronary artery disease
KW - Energy metabolism
KW - Physical deconditioning
KW - Propionyl-L-carnitine
KW - Skeletal muscle
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U2 - 10.1002/(SICI)1097-4598(199709)20:9<1115::AID-MUS4>3.0.CO;2-B
DO - 10.1002/(SICI)1097-4598(199709)20:9<1115::AID-MUS4>3.0.CO;2-B
M3 - Article
C2 - 9270666
AN - SCOPUS:0030872535
VL - 20
SP - 1115
EP - 1120
JO - Muscle and Nerve
JF - Muscle and Nerve
SN - 0148-639X
IS - 9
ER -