Changes in skeletal muscle histology and metabolism in patients undergoing exercise deconditioning: Effect of propionyl-L-carnitine

Gregorio Brevetti, Marina Fanin, Vincenzo De Amicis, Rosalba Carrozzo, Francesco D I Lello, Vincenzo Domenico Marione, Corrado Angelini

Research output: Contribution to journalArticlepeer-review

Abstract

To define the skeletal muscle abnormalities in patients undergoing exercise deconditioning and evaluate the metabolic effect of propionyl-L- carnitine (PLC), muscle biopsies were obtained from 28 patients with effort angina and 31 control subjects. Coronary artery disease patients received either placebo (n = 12), PLC (1.5 g IV followed by infusion of 1 mg/kg/min for 30 min, n = 10), or L-carnitine (1 g IV followed by infusion of 0.65 mg/kg/min for 30 min, n = 6) for 2 days. Exercise deconditioned patients treated with placebo showed normal muscle content of total carnitine and glycogen, and decrease in percentage of type 1 fibers (P

Original languageEnglish
Pages (from-to)1115-1120
Number of pages6
JournalMuscle and Nerve
Volume20
Issue number9
DOIs
Publication statusPublished - 1997

Keywords

  • Coronary artery disease
  • Energy metabolism
  • Physical deconditioning
  • Propionyl-L-carnitine
  • Skeletal muscle

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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