Changes in skeletal muscle histology and metabolism in patients undergoing exercise deconditioning: Effect of propionyl-L-carnitine

Gregorio Brevetti; Marina Fanin; Vincenzo De Amicis; Rosalba Carrozzo; Francesco D I Lello; Vincenzo Domenico Marione; Corrado Angelini

doi:10.1002/(SICI)1097-4598(199709)20:9<1115::AID-MUS4>3.0.CO;2-B

Changes in skeletal muscle histology and metabolism in patients undergoing exercise deconditioning: Effect of propionyl-L-carnitine

Gregorio Brevetti, Marina Fanin, Vincenzo De Amicis, Rosalba Carrozzo, Francesco D I Lello, Vincenzo Domenico Marione, Corrado Angelini

Research output: Contribution to journal › Article › peer-review

Abstract

To define the skeletal muscle abnormalities in patients undergoing exercise deconditioning and evaluate the metabolic effect of propionyl-L- carnitine (PLC), muscle biopsies were obtained from 28 patients with effort angina and 31 control subjects. Coronary artery disease patients received either placebo (n = 12), PLC (1.5 g IV followed by infusion of 1 mg/kg/min for 30 min, n = 10), or L-carnitine (1 g IV followed by infusion of 0.65 mg/kg/min for 30 min, n = 6) for 2 days. Exercise deconditioned patients treated with placebo showed normal muscle content of total carnitine and glycogen, and decrease in percentage of type 1 fibers (P

Original language	English
Pages (from-to)	1115-1120
Number of pages	6
Journal	Muscle and Nerve
Volume	20
Issue number	9
DOIs	https://doi.org/10.1002/(SICI)1097-4598(199709)20:9<1115::AID-MUS4>3.0.CO;2-B
Publication status	Published - 1997

Keywords

Coronary artery disease
Energy metabolism
Physical deconditioning
Propionyl-L-carnitine
Skeletal muscle

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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Changes in skeletal muscle histology and metabolism in patients undergoing exercise deconditioning : Effect of propionyl-L-carnitine. / Brevetti, Gregorio; Fanin, Marina; De Amicis, Vincenzo; Carrozzo, Rosalba; Lello, Francesco D I; Marione, Vincenzo Domenico; Angelini, Corrado.

In: Muscle and Nerve, Vol. 20, No. 9, 1997, p. 1115-1120.

Research output: Contribution to journal › Article › peer-review

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