TY - JOUR
T1 - Changes in somatosensory evoked potentials following forebrain ischemia in the gerbils
T2 - Effects of felbamate
AU - Arcadi, F. A.
AU - Lo Presti, R.
AU - Di Bella, P.
AU - Sessa, E.
AU - Imperatore, C.
AU - Salemi, M.
AU - Costa, G.
AU - Bramanti, P.
PY - 1999
Y1 - 1999
N2 - Somatosensory evoked potentials (SEPs) as well as change following transient cerebral ischemia in the gerbil were characterized in this study. SEPs were measured in each gerbil before ischemia (day -1), during ischemia, 10 min, 2, 4, 8, 24, 48 h and 8 days after recirculation. During bilateral carotid occlusion, SEP amplitude was dramatically reduced and central conduction time was significantly increased. During recirculation these values showed an improvement when compared to ischemic but not to control values. Moreover at 8 days of recirculation they were still statistically different from control values. Felbamate administration at the dose of 150 mg kg-1, immediately after recirculation was shown to ameliorate neurophysiological recovery following cerebral ischemia.
AB - Somatosensory evoked potentials (SEPs) as well as change following transient cerebral ischemia in the gerbil were characterized in this study. SEPs were measured in each gerbil before ischemia (day -1), during ischemia, 10 min, 2, 4, 8, 24, 48 h and 8 days after recirculation. During bilateral carotid occlusion, SEP amplitude was dramatically reduced and central conduction time was significantly increased. During recirculation these values showed an improvement when compared to ischemic but not to control values. Moreover at 8 days of recirculation they were still statistically different from control values. Felbamate administration at the dose of 150 mg kg-1, immediately after recirculation was shown to ameliorate neurophysiological recovery following cerebral ischemia.
KW - Cerebral ischemia
KW - Felbamate
KW - Gerbil
KW - Somatosensory evoked potentials
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M3 - Article
C2 - 10225354
AN - SCOPUS:0032894999
VL - 99
SP - 236
EP - 240
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
SN - 0001-6314
IS - 4
ER -