Changes in Subendocardial Viability Ratio in Traumatic Brain Injury Patients

Dorota Siwicka-Gieroba, Chiara Robba, Jan Poleszczuk, Malgorzata Debowska, Jacek Waniewski, Rafael Badenes, Andrzej Jaroszynski, Ewa Piasek, Katarzyna Kotfis, Jowita Biernawska, Wojciech Dabrowski

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Traumatic brain injury (TBI) is often associated with cardiac dysfunction, which is a consequence of the brain-heart cross talk. The subendocardial viability ratio (SEVR) is an estimate of myocardial perfusion. The aim of this study was to analyze changes in the SEVR in patients with severe TBI without previous cardiac diseases. Methods: Adult patients treated for severe TBI with a Glasgow coma score <8 were studied. Pressure waveforms were obtained by a high-fidelity tonometer in the radial artery for SEVR calculation at five time points: immediately after admission to the intensive care unit and 24, 48, 72, and 96 h after admission. SEVRs and other clinically important parameters were analyzed in patients who survived and did not survive after 28 days of treatment, as well as in patients who underwent decompressive craniectomy (DC). Results: A total of 64 patients (16 females and 48 males) aged 18-64 years were included. Fifty patients survived and 14 died. DC was performed in 23 patients. SEVRs decreased 24 h after admission in nonsurvivors (p < 0.05) and after 48 h in survivors (p < 0.01) and its values were significantly lower in nonsurvivors than in survivors at 24, 72, and 96 h from admission (p < 0.05). The SEVR increased following DC (p < 0.05). Conclusions: A decreased SEVR is observed in TBI patients. Surgical decompression increases the SEVR, indicating improvement in coronary microvascular perfusion. The results of our study seem to confirm that brain injury affects myocardium function.

Original languageEnglish
Pages (from-to)349-358
Number of pages10
JournalBrain Connectivity
Volume11
Issue number5
DOIs
Publication statusPublished - Jun 1 2021

Keywords

  • brain-heart cross-talk
  • decompressive craniectomy
  • myocardial perfusion
  • subendocardial viability ratio
  • traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)

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