TY - JOUR
T1 - Changes in subendocardial viability ratio with acute high-altitude exposure and protective role of acetazolamide
AU - Salvi, Paolo
AU - Revera, Miriam
AU - Faini, Andrea
AU - Giuliano, Andrea
AU - Gregorini, Francesca
AU - Agostoni, Piergiuseppe
AU - Becerra, Carlos G.
AU - Bilo, Grzegorz
AU - Lombardi, Carolina
AU - O'Rourke, Michael F.
AU - Mancia, Giuseppe
AU - Parati, Gianfranco
PY - 2013/4
Y1 - 2013/4
N2 - High-altitude tourism is increasingly frequent, involving also subjects with manifest or subclinical coronary artery disease. Little is known, however, on the effects of altitude exposure on factors affecting coronary perfusion. The aim of our study was to assess myocardial oxygen supply/demand ratio in healthy subjects during acute exposure at high altitude and to evaluate the effect of acetazolamide on this parameter. Forty-four subjects (21 men, age range: 24-59 years) were randomized to double-blind acetazolamide 250 mg bid or placebo. Subendocardial viability ratio and oxygen supply/demand ratio were estimated on carotid artery by means of a validated PulsePen tonometer, at sea level, before and after treatment, and after acute and more prolonged exposure to high altitude (4559 m). On arrival at high altitude, subendocardial viability ratio was reduced in both placebo (from 1.63±0.15 to 1.18±0.17; P
AB - High-altitude tourism is increasingly frequent, involving also subjects with manifest or subclinical coronary artery disease. Little is known, however, on the effects of altitude exposure on factors affecting coronary perfusion. The aim of our study was to assess myocardial oxygen supply/demand ratio in healthy subjects during acute exposure at high altitude and to evaluate the effect of acetazolamide on this parameter. Forty-four subjects (21 men, age range: 24-59 years) were randomized to double-blind acetazolamide 250 mg bid or placebo. Subendocardial viability ratio and oxygen supply/demand ratio were estimated on carotid artery by means of a validated PulsePen tonometer, at sea level, before and after treatment, and after acute and more prolonged exposure to high altitude (4559 m). On arrival at high altitude, subendocardial viability ratio was reduced in both placebo (from 1.63±0.15 to 1.18±0.17; P
KW - acetazolamide
KW - altitude
KW - arterial stiffness
KW - hypobaric hypoxia
KW - myocardial oxygen demand
KW - pulse wave analysis
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U2 - 10.1161/HYPERTENSIONAHA.111.00707
DO - 10.1161/HYPERTENSIONAHA.111.00707
M3 - Article
C2 - 23438935
AN - SCOPUS:84875211260
VL - 61
SP - 793
EP - 799
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 4
ER -