Changes in subendocardial viability ratio with acute high-altitude exposure and protective role of acetazolamide

Paolo Salvi, Miriam Revera, Andrea Faini, Andrea Giuliano, Francesca Gregorini, Piergiuseppe Agostoni, Carlos G. Becerra, Grzegorz Bilo, Carolina Lombardi, Michael F. O'Rourke, Giuseppe Mancia, Gianfranco Parati

Research output: Contribution to journalArticlepeer-review

Abstract

High-altitude tourism is increasingly frequent, involving also subjects with manifest or subclinical coronary artery disease. Little is known, however, on the effects of altitude exposure on factors affecting coronary perfusion. The aim of our study was to assess myocardial oxygen supply/demand ratio in healthy subjects during acute exposure at high altitude and to evaluate the effect of acetazolamide on this parameter. Forty-four subjects (21 men, age range: 24-59 years) were randomized to double-blind acetazolamide 250 mg bid or placebo. Subendocardial viability ratio and oxygen supply/demand ratio were estimated on carotid artery by means of a validated PulsePen tonometer, at sea level, before and after treatment, and after acute and more prolonged exposure to high altitude (4559 m). On arrival at high altitude, subendocardial viability ratio was reduced in both placebo (from 1.63±0.15 to 1.18±0.17; P

Original languageEnglish
Pages (from-to)793-799
Number of pages7
JournalHypertension
Volume61
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords

  • acetazolamide
  • altitude
  • arterial stiffness
  • hypobaric hypoxia
  • myocardial oxygen demand
  • pulse wave analysis

ASJC Scopus subject areas

  • Internal Medicine

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