Changes in the ADP-ribosylation status of some hippocampal proteins are linked to kindling progression

Annamaria Vezzani, Stefano Sparvoli, Massimo Rizzi, Mirella Zinetti, Maddalena Fratelli

Research output: Contribution to journalArticlepeer-review

Abstract

The N-methyl-D-aspartate (NMDA) receptors are a class of excitatory amino acid receptors in the hrain which are important for the induction of kindling and kindling-like phenomena. Post hoc sodium nitroprusside-induced ADP ribosylation of some proteins (particularly a p43 and a p39 protein) in homogenates from stimulated hippocampus was reduced at preconvulsive stage II and stage V (tonic-clonic seizures) of dentate gyrus kindling compared with controls. This effect, which probably reflects enhanced endogenous ADP ribosylation, depends on the progressive activation of the NMDA receptors and on the generation of nitric oxide (NO). The early occurrence and the persistence of these modifications suggest they may be associated to the long-lasting changes in neuronal function induced by kindling.

Original languageEnglish
Pages (from-to)1217-1220
Number of pages4
JournalNeuroReport
Volume5
Issue number10
Publication statusPublished - 1994

Keywords

  • ADP-ribosylation
  • Hippocampus
  • Kindling
  • N-methyl-D-aspartate receptors
  • Neuronal plasticity
  • Nitric oxide
  • Nitric oxide synthase
  • Rat
  • Seizures

ASJC Scopus subject areas

  • Neuroscience(all)

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