Changes in the ADP-ribosylation status of some hippocampal proteins are linked to kindling progression

Annamaria Vezzani; Stefano Sparvoli; Massimo Rizzi; Mirella Zinetti; Maddalena Fratelli

Changes in the ADP-ribosylation status of some hippocampal proteins are linked to kindling progression

Annamaria Vezzani, Stefano Sparvoli, Massimo Rizzi, Mirella Zinetti, Maddalena Fratelli

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The N-methyl-D-aspartate (NMDA) receptors are a class of excitatory amino acid receptors in the hrain which are important for the induction of kindling and kindling-like phenomena. Post hoc sodium nitroprusside-induced ADP ribosylation of some proteins (particularly a p43 and a p39 protein) in homogenates from stimulated hippocampus was reduced at preconvulsive stage II and stage V (tonic-clonic seizures) of dentate gyrus kindling compared with controls. This effect, which probably reflects enhanced endogenous ADP ribosylation, depends on the progressive activation of the NMDA receptors and on the generation of nitric oxide (NO). The early occurrence and the persistence of these modifications suggest they may be associated to the long-lasting changes in neuronal function induced by kindling.

Original language	English
Pages (from-to)	1217-1220
Number of pages	4
Journal	NeuroReport
Volume	5
Issue number	10
Publication status	Published - 1994

Keywords

ADP-ribosylation
Hippocampus
Kindling
N-methyl-D-aspartate receptors
Neuronal plasticity
Nitric oxide
Nitric oxide synthase
Rat
Seizures

ASJC Scopus subject areas

Neuroscience(all)

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title = "Changes in the ADP-ribosylation status of some hippocampal proteins are linked to kindling progression",

abstract = "The N-methyl-D-aspartate (NMDA) receptors are a class of excitatory amino acid receptors in the hrain which are important for the induction of kindling and kindling-like phenomena. Post hoc sodium nitroprusside-induced ADP ribosylation of some proteins (particularly a p43 and a p39 protein) in homogenates from stimulated hippocampus was reduced at preconvulsive stage II and stage V (tonic-clonic seizures) of dentate gyrus kindling compared with controls. This effect, which probably reflects enhanced endogenous ADP ribosylation, depends on the progressive activation of the NMDA receptors and on the generation of nitric oxide (NO). The early occurrence and the persistence of these modifications suggest they may be associated to the long-lasting changes in neuronal function induced by kindling.",

keywords = "ADP-ribosylation, Hippocampus, Kindling, N-methyl-D-aspartate receptors, Neuronal plasticity, Nitric oxide, Nitric oxide synthase, Rat, Seizures",

author = "Annamaria Vezzani and Stefano Sparvoli and Massimo Rizzi and Mirella Zinetti and Maddalena Fratelli",

year = "1994",

language = "English",

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pages = "1217--1220",

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T1 - Changes in the ADP-ribosylation status of some hippocampal proteins are linked to kindling progression

AU - Vezzani, Annamaria

AU - Sparvoli, Stefano

AU - Rizzi, Massimo

AU - Zinetti, Mirella

AU - Fratelli, Maddalena

PY - 1994

Y1 - 1994

N2 - The N-methyl-D-aspartate (NMDA) receptors are a class of excitatory amino acid receptors in the hrain which are important for the induction of kindling and kindling-like phenomena. Post hoc sodium nitroprusside-induced ADP ribosylation of some proteins (particularly a p43 and a p39 protein) in homogenates from stimulated hippocampus was reduced at preconvulsive stage II and stage V (tonic-clonic seizures) of dentate gyrus kindling compared with controls. This effect, which probably reflects enhanced endogenous ADP ribosylation, depends on the progressive activation of the NMDA receptors and on the generation of nitric oxide (NO). The early occurrence and the persistence of these modifications suggest they may be associated to the long-lasting changes in neuronal function induced by kindling.

AB - The N-methyl-D-aspartate (NMDA) receptors are a class of excitatory amino acid receptors in the hrain which are important for the induction of kindling and kindling-like phenomena. Post hoc sodium nitroprusside-induced ADP ribosylation of some proteins (particularly a p43 and a p39 protein) in homogenates from stimulated hippocampus was reduced at preconvulsive stage II and stage V (tonic-clonic seizures) of dentate gyrus kindling compared with controls. This effect, which probably reflects enhanced endogenous ADP ribosylation, depends on the progressive activation of the NMDA receptors and on the generation of nitric oxide (NO). The early occurrence and the persistence of these modifications suggest they may be associated to the long-lasting changes in neuronal function induced by kindling.

KW - ADP-ribosylation

KW - Hippocampus

KW - Kindling

KW - N-methyl-D-aspartate receptors

KW - Neuronal plasticity

KW - Nitric oxide

KW - Nitric oxide synthase

KW - Rat

KW - Seizures

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Changes in the ADP-ribosylation status of some hippocampal proteins are linked to kindling progression

Abstract

Keywords

ASJC Scopus subject areas

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