Changes in the immune responses against human herpesvirus-8 in the disease course of posttransplant kaposi sarcoma

Patrizia Barozzi, Chiara Bonini, Leonardo Potenza, Michele Masetti, Gianni Cappelli, Paola Gruarin, Denise Whitby, Giorgio E. Gerunda, Anna Mondino, Giovanni Riva, Daniela Vallerini, Chiara Quadrelli, Raffaella Bosco, Fabio Ciceri, Claudio Bordignon, Thomas F. Schulz, Giuseppe Torelli, Mario Luppi

Research output: Contribution to journalArticlepeer-review

Abstract

In nine patients with posttransplant Kaposi sarcoma (KS) T-cell responses to human herpesvirus (HHV)-8 latent and lytic antigens, as detected by enzyme-linked-immunospot (Elispot) assay, were absent at disease onset. Virus-specific T-cell responses were detected in six renal recipients at remission after a reduction of calcineurin inhibitors (CIs), and in two HHV-8 seropositive renal recipients without KS. In two liver recipients undergoing switch from CIs to sirolimus (SRL), normalization of the T-cell repertoire and recovery of both HHV-8-specific effector and memory T lymphocytes were associated with complete KS remission. In a renal recipient undergoing SRL conversion, the early recovery of HHV-8-specific effector but not of memory T lymphocytes, was associated only with partial remission. Neither rejection nor changes in graft function were observed after SRL conversion. HHV-8-specific T-cell responses are required to achieve posttransplant KS remission, and may be restored under SRL, while maintaining effective immunosuppression.

Original languageEnglish
Pages (from-to)738-744
Number of pages7
JournalTransplantation
Volume86
Issue number5
DOIs
Publication statusPublished - Sep 15 2008

Keywords

  • HHV-8
  • Immunity
  • Posttransplant Kaposi sarcoma
  • Sirolimus

ASJC Scopus subject areas

  • Transplantation

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