Modificazioni del profilo immunologico in pazienti diabetici neo diagnosticati nel corso del primo anno di malattia.

Translated title of the contribution: Changes in the immunologic profile of newly-diagnosed diabetic patients during the first year of the disease

M. G. Pizzul, C. Betterle, C. De Campo, G. Tonini, S. Marinoni, M. Pocecco

Research output: Contribution to journalArticle

Abstract

Immunological markers including ICA-IgG, CF-ICA, other non organ specific autoantibodies, circulating immune complexes (CIC), IgG, IgA, IgM, C3, C4 and lymphocyte subpopulations (OKT3, OKT4, OKT8) were studied at onset in 32 insulin dependent diabetic patients (16 males, 16 females, aged 1-21 yr.). Other non organ specific autoantibodies, CIC, IgG, IgA, IgM, C3, C4 and OKT3, OKT4, OKT8 were also studied after a 6-12 months follow-up in the same group of patients. ICA-IgG and CF-ICA were also studied in a control group of 19 insulin dependent diabetic patients with an over 3 year history of diabetes. ICA IgC, CF-ICA, other autoantibodies and CIC were detected at diagnosis in 65%, 19%, 33%, and 50% of patients respectively. ICA-IgG and FC-ICA were detected respectively in 15% and zero of the control group of 19 long standing diabetes. No alterations in IgG, C3 and C4 levels and in T cells subsets have been found at onset. C4 levels significantly decreased at the successive observation. A significant elevation of IgG levels and helper/suppressor ratio were also observed at follow-up. Autoantibodies and CIC positive sera at diagnosis support the concept that a previous autoimmune disorder exists before clinical manifestations of diabetes. Other immunological abnormalities including relative hypogammaglobulinemie, lower C4 and higher helper/suppressor ratio, observed by other authors (Kanakoudi 1984, Vergani 1985, Lernmark 1985) represent an aspecific alteration due to metabolic imbalance or to an earlier immunological disorder.

Translated title of the contributionChanges in the immunologic profile of newly-diagnosed diabetic patients during the first year of the disease
Original languageItalian
Pages (from-to)481-485
Number of pages5
JournalPediatria Medica e Chirurgica
Volume10
Issue number5
Publication statusPublished - Sep 1988

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Changes in the immunologic profile of newly-diagnosed diabetic patients during the first year of the disease'. Together they form a unique fingerprint.

  • Cite this

    Pizzul, M. G., Betterle, C., De Campo, C., Tonini, G., Marinoni, S., & Pocecco, M. (1988). Modificazioni del profilo immunologico in pazienti diabetici neo diagnosticati nel corso del primo anno di malattia. Pediatria Medica e Chirurgica, 10(5), 481-485.