MODIFICAZIONI DEL COMPARTIMENTO RECETTORIALE DOPAMINERGICO NIGROSTRIATALE DOPO INFUSIONE DOPAMINERGICA CONTINUA NEL MORBO DI PARKINSON

Translated title of the contribution: Changes in the nigrostriatal dopaminergic receptor system following continuous dopaminergic infusion in Parkinson's disease

F. Baronti, S. Ruggieri, M. M. Mouradian, A. Bonamartini, P. Bocciarelli, M. F. De Pandis, T. N. Chase, A. Agnoli

Research output: Contribution to journalArticle

Abstract

Motor fluctuations often complicate chronic levodopa treatment of Parkinson's disease. Pharmacologically, these phenomena are characterized by a progressive shortening of the duration of action of levodopa and a gradual narrowing of the range of 'optimally effective' doses, able to improve parkinsonian akinesia without including abnormal involuntary movements. The effects of a continuous intravenous infusion of levodopa lasting 9 ± 0.3 days on these clinical-pharmacological indices have been studied in 12 parkinsonian patients. Continuous infusion therapy gradually ameliorated motor fluctuations by more than 40%, and this improvement lasted for at least 6 days after resuming standard oral therapy. Moreover, levodopa duration of action was prolonged by about 30%, and the range of 'optimally effective' dose was widened by about 50%. The above data suggest the possibility of plastic modifications of the pathogenetic mechanisms underlying motor fluctuations in Parkinson's disease, and a potential deleterious effect of intermittent oral therapy. Consequently, continuous dopaminergic stimulation, when used in the early stages of the disease, might theoretically have a prophylactic role on the development or worsening of motor fluctuations.

Translated title of the contributionChanges in the nigrostriatal dopaminergic receptor system following continuous dopaminergic infusion in Parkinson's disease
Original languageItalian
Pages (from-to)210-214
Number of pages5
JournalRivista di Neurologia
Volume61
Issue number6
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Clinical Neurology

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    Baronti, F., Ruggieri, S., Mouradian, M. M., Bonamartini, A., Bocciarelli, P., De Pandis, M. F., Chase, T. N., & Agnoli, A. (1991). MODIFICAZIONI DEL COMPARTIMENTO RECETTORIALE DOPAMINERGICO NIGROSTRIATALE DOPO INFUSIONE DOPAMINERGICA CONTINUA NEL MORBO DI PARKINSON. Rivista di Neurologia, 61(6), 210-214.