Alterazioni della produzione di IgM in risposta al pokeweed mitogen nell'artrite reumatoide giovanile. Correlazioni con l'attività della malattia.

Translated title of the contribution: Changes in the production of IgM in response to pokeweed mitogen in juvenile rheumatoid arthritis. Correlations with disease activity

M. Massa, M. De Amici, A. Ravelli, S. Albani, S. Viola, F. De Benedetti, M. C. Giaccari, A. Martini

Research output: Contribution to journalArticlepeer-review

Abstract

Unstimulated and pokeweed mitogen (PWM)-stimulated "in vitro" IgM synthesis by peripheral blood lymphocytes has been evaluated by an ELISA method in 33 patients with juvenile rheumatoid arthritis (JRA). Lymphocyte PWM responses were significantly reduced in patients with JRA compared with healthy controls. When patients were divided according to disease activity, a significant increase of stimulation index (ratio of IgM synthesis with over that without PWM) has been observed in patients with disease remission compared with those with active disease. These findings confirm the defect in PWM-induced IgM synthesis by peripheral blood lymphocytes of patients with JRA and suggest that these abnormalities may be related to disease activity.

Translated title of the contributionChanges in the production of IgM in response to pokeweed mitogen in juvenile rheumatoid arthritis. Correlations with disease activity
Original languageItalian
Pages (from-to)273-276
Number of pages4
JournalMinerva Pediatrica
Volume42
Issue number7-8
Publication statusPublished - Jul 1990

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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