Alterazioni della secrezione di ormone somatotropo ed insulina nell'ipertiroidismo

Translated title of the contribution: Changes in the secretion of somatotropin and insulin in hyperthyroidism

F. Cavagnini, M. Peracchi, A. E. Panerai, M. Pinto

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty hyperthyroid patients were investigated for growth hormone (GH) and immunoreactive insulin (IRI) secretion in response to insulin hypoglycaemia, arginine infusion and glucose-induced hyperglycaemia. GH response to either insulin hypoglycaemia or arginine infusion was significantly reduced in these patients compared with 20 normal subjects. Thyrotoxic patients also displayed an abnormal GH pattern after a 100 g oral glucose load: in fact, serum GH underwent a paradoxical increase in spite of abnormally high levels attained by blood glucose. IRI secretion was also clearly reduced in response to arginine infusion and moderately blunted after oral glucose. In a group of patients re-evaluated under euthyroid conditions, a fair increase of GH response to the provocative stimuli jointly with the restoration of a normal suppressibility of serum GH by glucose were noted; by contrast, no significant change of IRI response to arginine or glucose took place. Likewise, the impairment of glucose tolerance was not improved. These findings indicate that an impairment of GH and IRI secretion is present in hyperthyroidism. The possibility that a potentiation of the catecholamine effects caused by the thyroid hormones is involved in this alteration deserves consideration.

Translated title of the contributionChanges in the secretion of somatotropin and insulin in hyperthyroidism
Original languageItalian
Pages (from-to)372-381
Number of pages10
JournalQuaderni Sclavo di diagnostica clinica e di laboratorio
Volume11
Issue number2
Publication statusPublished - Jun 1975

ASJC Scopus subject areas

  • Medicine(all)

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