TY - JOUR
T1 - Changes in the size of rectovaginal endometriotic nodules infiltrating the rectum during hormonal therapies
AU - Ferrero, Simone
AU - Leone Roberti Maggiore, Umberto
AU - Scala, Carolina
AU - Di Luca, Martina
AU - Venturini, Pier Luigi
AU - Remorgida, Valentino
PY - 2013/3
Y1 - 2013/3
N2 - Purpose: To evaluate the changes in the volume of rectovaginal endometriotic nodules infiltrating the rectum during 12-month treatment with hormonal therapies. Materials and methods: This prospective, non-randomized, self-controlled clinical trial included patients with rectovaginal endometriotic nodules infiltrating at least the muscularis propria of the rectum, who received one of the following therapies: norethisterone acetate, triptorelin and tibolone, norethisterone acetate and letrozole, desogestrel, sequential oral contraceptive pill. The volume of the nodules was determined by virtual organ computer-aided analysis (VOCAL, GE Healthcare, USA) at baseline and after 6 and 12 months of treatment. Results: Eighty-three women (90.2 %) completed the 12-month treatment. When compared with baseline values, the volume of the nodules decreased at 6-month (p <0.001) and 12-month treatment (p <0.001). After 12-month treatment, the volume of the nodules decreased in all study groups. The volume of the nodules decreased during therapy in 68 women (73.9 %) and increased in 11 women (12.0 %). Conclusion: 12-month administration of hormonal therapies reduces the volume of rectovaginal endometriotic nodules infiltrating the rectum in the majority of cases.
AB - Purpose: To evaluate the changes in the volume of rectovaginal endometriotic nodules infiltrating the rectum during 12-month treatment with hormonal therapies. Materials and methods: This prospective, non-randomized, self-controlled clinical trial included patients with rectovaginal endometriotic nodules infiltrating at least the muscularis propria of the rectum, who received one of the following therapies: norethisterone acetate, triptorelin and tibolone, norethisterone acetate and letrozole, desogestrel, sequential oral contraceptive pill. The volume of the nodules was determined by virtual organ computer-aided analysis (VOCAL, GE Healthcare, USA) at baseline and after 6 and 12 months of treatment. Results: Eighty-three women (90.2 %) completed the 12-month treatment. When compared with baseline values, the volume of the nodules decreased at 6-month (p <0.001) and 12-month treatment (p <0.001). After 12-month treatment, the volume of the nodules decreased in all study groups. The volume of the nodules decreased during therapy in 68 women (73.9 %) and increased in 11 women (12.0 %). Conclusion: 12-month administration of hormonal therapies reduces the volume of rectovaginal endometriotic nodules infiltrating the rectum in the majority of cases.
KW - Desogestrel
KW - Letrozole
KW - Medical therapy
KW - Norethisterone acetate
KW - Rectal endometriosis
KW - Rectovaginal endometriosis
KW - Virtual organ computer-aided analysis
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U2 - 10.1007/s00404-012-2581-2
DO - 10.1007/s00404-012-2581-2
M3 - Article
C2 - 23053314
AN - SCOPUS:84878359292
VL - 287
SP - 447
EP - 453
JO - Archives of Gynecology
JF - Archives of Gynecology
SN - 0170-9925
IS - 3
ER -