Changes in the synthesis of histone Hl° and Hl in rat FRTL-5 thyroid cells exposed to thyrotropin

Cecilia Mannironi, Eugenio Erba, Daniela Corda, Laura Gianellini, Maurizio D'Incalci

Research output: Contribution to journalArticlepeer-review

Abstract

In absence of thyrotropin (TSH), FRTL-5 rat thyroid cells stop proliferating and lose the functional characteristics of thyroid tissue. FRTL-5 cells regain their differentiated state and their proliferation activity upon addition of TSH. In this study we investigated the synthesis of histone Hl variants and Hl° in FRTL-5 cells exposed to 10-8 M TSH, two days after TSH withdrawal. TSH induced the synthesis of some Hl variants and Hl°. This effect was already evident six hours after TSH addition, thus well before proliferation, DNA or thyroglobulin synthesis was induced. These data indicate that the induction of Hl° and some Hl variants is an early event after TSH stimulation and may thus be related to the functional differentation of FRTL-5 cells.

Original languageEnglish
Pages (from-to)2209-2216
Number of pages8
JournalLife Sciences
Volume45
Issue number23
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmacology

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