Changes in the synthesis of histone Hl° and Hl in rat FRTL-5 thyroid cells exposed to thyrotropin

Cecilia Mannironi; Eugenio Erba; Daniela Corda; Laura Gianellini; Maurizio D'Incalci

doi:10.1016/0024-3205(89)90061-1

Changes in the synthesis of histone Hl° and Hl in rat FRTL-5 thyroid cells exposed to thyrotropin

Cecilia Mannironi, Eugenio Erba, Daniela Corda, Laura Gianellini, Maurizio D'Incalci

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

In absence of thyrotropin (TSH), FRTL-5 rat thyroid cells stop proliferating and lose the functional characteristics of thyroid tissue. FRTL-5 cells regain their differentiated state and their proliferation activity upon addition of TSH. In this study we investigated the synthesis of histone Hl variants and Hl° in FRTL-5 cells exposed to 10^-8 M TSH, two days after TSH withdrawal. TSH induced the synthesis of some Hl variants and Hl°. This effect was already evident six hours after TSH addition, thus well before proliferation, DNA or thyroglobulin synthesis was induced. These data indicate that the induction of Hl° and some Hl variants is an early event after TSH stimulation and may thus be related to the functional differentation of FRTL-5 cells.

Original language	English
Pages (from-to)	2209-2216
Number of pages	8
Journal	Life Sciences
Volume	45
Issue number	23
DOIs	https://doi.org/10.1016/0024-3205(89)90061-1
Publication status	Published - 1989

ASJC Scopus subject areas

Pharmacology

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title = "Changes in the synthesis of histone Hl° and Hl in rat FRTL-5 thyroid cells exposed to thyrotropin",

abstract = "In absence of thyrotropin (TSH), FRTL-5 rat thyroid cells stop proliferating and lose the functional characteristics of thyroid tissue. FRTL-5 cells regain their differentiated state and their proliferation activity upon addition of TSH. In this study we investigated the synthesis of histone Hl variants and Hl° in FRTL-5 cells exposed to 10-8 M TSH, two days after TSH withdrawal. TSH induced the synthesis of some Hl variants and Hl°. This effect was already evident six hours after TSH addition, thus well before proliferation, DNA or thyroglobulin synthesis was induced. These data indicate that the induction of Hl° and some Hl variants is an early event after TSH stimulation and may thus be related to the functional differentation of FRTL-5 cells.",

author = "Cecilia Mannironi and Eugenio Erba and Daniela Corda and Laura Gianellini and Maurizio D'Incalci",

year = "1989",

doi = "10.1016/0024-3205(89)90061-1",

language = "English",

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pages = "2209--2216",

journal = "Life Sciences",

issn = "0024-3205",

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T1 - Changes in the synthesis of histone Hl° and Hl in rat FRTL-5 thyroid cells exposed to thyrotropin

AU - Mannironi, Cecilia

AU - Erba, Eugenio

AU - Corda, Daniela

AU - Gianellini, Laura

AU - D'Incalci, Maurizio

PY - 1989

Y1 - 1989

N2 - In absence of thyrotropin (TSH), FRTL-5 rat thyroid cells stop proliferating and lose the functional characteristics of thyroid tissue. FRTL-5 cells regain their differentiated state and their proliferation activity upon addition of TSH. In this study we investigated the synthesis of histone Hl variants and Hl° in FRTL-5 cells exposed to 10-8 M TSH, two days after TSH withdrawal. TSH induced the synthesis of some Hl variants and Hl°. This effect was already evident six hours after TSH addition, thus well before proliferation, DNA or thyroglobulin synthesis was induced. These data indicate that the induction of Hl° and some Hl variants is an early event after TSH stimulation and may thus be related to the functional differentation of FRTL-5 cells.

AB - In absence of thyrotropin (TSH), FRTL-5 rat thyroid cells stop proliferating and lose the functional characteristics of thyroid tissue. FRTL-5 cells regain their differentiated state and their proliferation activity upon addition of TSH. In this study we investigated the synthesis of histone Hl variants and Hl° in FRTL-5 cells exposed to 10-8 M TSH, two days after TSH withdrawal. TSH induced the synthesis of some Hl variants and Hl°. This effect was already evident six hours after TSH addition, thus well before proliferation, DNA or thyroglobulin synthesis was induced. These data indicate that the induction of Hl° and some Hl variants is an early event after TSH stimulation and may thus be related to the functional differentation of FRTL-5 cells.

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