Changes in transcription activity in the rat brain following the acute administration of typical and atypical neuroleptics

P. Barone, C. Fiorillo, A. Morone, C. Vitale, A. De Bartolomeis

Research output: Contribution to journalArticle

Abstract

Parkinsonism and acute dystonic reactions are extrapyramidal side effects that commonly occur soon after the treatment with typical neuroleptics. A new class of antipsychotic drugs, known as atypical neuroleptics. has shown to have a low incidence of extrapyramidal side effects. The aim of the present study is to estimate the possible differences in activation of transcription complexes in striatal and cortical neurons after acute administration of a typical neuroleptic. haloperidol (HAL) versus an atypical one, olanzapine (OLA). Particulary, we have examined the DNA binding activity and the expression of members of CREB/ATF, AP-1 and NFkB families in nuclear extracts of cortex and striatum of rats receiving either HAL (2 mg/kg), OLA (10 mg/kg). or 0.9% NaCl (control animals). In striatum the acute administration of HAL increases AP-1 binding whereas CREB/ATF and NFkB binding activites show no alterations. In cortex CREB/ATF and NFkB significantly increase after OLA treatment whereas the administration of HAL induces no effects on both striatal and cortical transcription factors. The present results suggest that transcription factor alterations may be correlated with both clinical efficacy and adverse reactions.

Original languageEnglish
Pages (from-to)271-272
Number of pages2
JournalItalian Journal of Neurological Sciences
Volume20
Issue number4
Publication statusPublished - 1999

Fingerprint

olanzapine
Haloperidol
Antipsychotic Agents
Corpus Striatum
Transcription Factor AP-1
Brain
Transcription Factors
Parkinsonian Disorders
Nuclear Family
Transcriptional Activation
Neurons
DNA
Incidence

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Changes in transcription activity in the rat brain following the acute administration of typical and atypical neuroleptics. / Barone, P.; Fiorillo, C.; Morone, A.; Vitale, C.; De Bartolomeis, A.

In: Italian Journal of Neurological Sciences, Vol. 20, No. 4, 1999, p. 271-272.

Research output: Contribution to journalArticle

@article{869fcc00d7924e708ad732a9bb94ce6b,
title = "Changes in transcription activity in the rat brain following the acute administration of typical and atypical neuroleptics",
abstract = "Parkinsonism and acute dystonic reactions are extrapyramidal side effects that commonly occur soon after the treatment with typical neuroleptics. A new class of antipsychotic drugs, known as atypical neuroleptics. has shown to have a low incidence of extrapyramidal side effects. The aim of the present study is to estimate the possible differences in activation of transcription complexes in striatal and cortical neurons after acute administration of a typical neuroleptic. haloperidol (HAL) versus an atypical one, olanzapine (OLA). Particulary, we have examined the DNA binding activity and the expression of members of CREB/ATF, AP-1 and NFkB families in nuclear extracts of cortex and striatum of rats receiving either HAL (2 mg/kg), OLA (10 mg/kg). or 0.9{\%} NaCl (control animals). In striatum the acute administration of HAL increases AP-1 binding whereas CREB/ATF and NFkB binding activites show no alterations. In cortex CREB/ATF and NFkB significantly increase after OLA treatment whereas the administration of HAL induces no effects on both striatal and cortical transcription factors. The present results suggest that transcription factor alterations may be correlated with both clinical efficacy and adverse reactions.",
author = "P. Barone and C. Fiorillo and A. Morone and C. Vitale and {De Bartolomeis}, A.",
year = "1999",
language = "English",
volume = "20",
pages = "271--272",
journal = "Italian Journal of Neurological Sciences",
issn = "0392-0461",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Changes in transcription activity in the rat brain following the acute administration of typical and atypical neuroleptics

AU - Barone, P.

AU - Fiorillo, C.

AU - Morone, A.

AU - Vitale, C.

AU - De Bartolomeis, A.

PY - 1999

Y1 - 1999

N2 - Parkinsonism and acute dystonic reactions are extrapyramidal side effects that commonly occur soon after the treatment with typical neuroleptics. A new class of antipsychotic drugs, known as atypical neuroleptics. has shown to have a low incidence of extrapyramidal side effects. The aim of the present study is to estimate the possible differences in activation of transcription complexes in striatal and cortical neurons after acute administration of a typical neuroleptic. haloperidol (HAL) versus an atypical one, olanzapine (OLA). Particulary, we have examined the DNA binding activity and the expression of members of CREB/ATF, AP-1 and NFkB families in nuclear extracts of cortex and striatum of rats receiving either HAL (2 mg/kg), OLA (10 mg/kg). or 0.9% NaCl (control animals). In striatum the acute administration of HAL increases AP-1 binding whereas CREB/ATF and NFkB binding activites show no alterations. In cortex CREB/ATF and NFkB significantly increase after OLA treatment whereas the administration of HAL induces no effects on both striatal and cortical transcription factors. The present results suggest that transcription factor alterations may be correlated with both clinical efficacy and adverse reactions.

AB - Parkinsonism and acute dystonic reactions are extrapyramidal side effects that commonly occur soon after the treatment with typical neuroleptics. A new class of antipsychotic drugs, known as atypical neuroleptics. has shown to have a low incidence of extrapyramidal side effects. The aim of the present study is to estimate the possible differences in activation of transcription complexes in striatal and cortical neurons after acute administration of a typical neuroleptic. haloperidol (HAL) versus an atypical one, olanzapine (OLA). Particulary, we have examined the DNA binding activity and the expression of members of CREB/ATF, AP-1 and NFkB families in nuclear extracts of cortex and striatum of rats receiving either HAL (2 mg/kg), OLA (10 mg/kg). or 0.9% NaCl (control animals). In striatum the acute administration of HAL increases AP-1 binding whereas CREB/ATF and NFkB binding activites show no alterations. In cortex CREB/ATF and NFkB significantly increase after OLA treatment whereas the administration of HAL induces no effects on both striatal and cortical transcription factors. The present results suggest that transcription factor alterations may be correlated with both clinical efficacy and adverse reactions.

UR - http://www.scopus.com/inward/record.url?scp=33746370120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746370120&partnerID=8YFLogxK

M3 - Article

VL - 20

SP - 271

EP - 272

JO - Italian Journal of Neurological Sciences

JF - Italian Journal of Neurological Sciences

SN - 0392-0461

IS - 4

ER -