Changes in unbound and total valproic acid concentrations after replacement of carbamazepine with oxcarbazepine

D. Battino, D. Croci, T. Granata, G. Bernardi, G. Monza

Research output: Contribution to journalArticlepeer-review

Abstract

Total and free valproic acid (VPA) concentrations were measured in patients switched from a combined VPA and carbamazepine (CBZ) to a combined VPA and oxcarbazepine (OXC) therapy, both administered in individualized daily doses. Four young epileptic patients (13–17 years old) were studied for a 12-week period, total and free VPA concentrations being analyzed just before and 4 h after the morning dose, at the end of VPA and CBZ therapy, and 2 and 10 weeks after CBZ was replaced by OXC. The expected increase in the level/dose (L/D) ratio of total VPA observed at the end of the study was preceded by a clear-cut increase in the L/D ratio of free VPA, which led to VPA-related side effects and required the retitration of VPA daily doses.

Original languageEnglish
Pages (from-to)376-379
Number of pages4
JournalTherapeutic Drug Monitoring
Volume14
Issue number5
Publication statusPublished - 1992

Keywords

  • Carbamazepine
  • Oxcarbazepine
  • Pharmacokinetics
  • Valproic acid

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Toxicology

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