Changes observed in slow-growing melanomas during long-term dermoscopic monitoring

V. Terushkin, S. W. Dusza, A. Scope, G. Argenziano, P. Bahadoran, L. Cowell, V. De Giorgi, G. Ferrara, H. Kittler, J. Malvehy, S. Menzies, D. Piccolo, S. Puig, P. Rubegni, I. Stanganelli, L. Thomas, I. Zalaudek, A. A. Marghoob

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Abstract

Background: Melanomas vary in growth rate from rapidly developing nodular melanomas to slow-growing melanomas (SGM) that hardly change over years. Objectives: To evaluate longitudinal changes in dermoscopic findings of SGM. Methods We retrospectively analysed a dermoscopic image dataset from 15 pigmented lesion clinics, of SGM that were followed sequentially by digital dermoscopy for at least 1 year. We evaluated baseline and follow-up images for changes in global pattern, organization, colours, structure and size. Results: Our series consisted of 92 SGM. On follow-up, these melanomas developed the following dermoscopic findings: more homogeneous and less reticular global dermoscopic pattern; more frequent disorganization of pattern (baseline, 67% vs. follow-up, 79%); decreased prominence of light brown colour, increased prominence of dark brown colour, and increased frequency of the colours red, white, grey, blue and black (baseline: 29%, 3%, 18%, 6% and 33% vs. follow-up: 41%, 10%, 31%, 13% and 45%, respectively); decrease in prominence of dermoscopic structure of pigmented network, with a concomitant increase in prominence of structureless areas; and increased prominence or new appearance of melanoma-specific dermoscopic structures, including negative network, blue-white structures and blotches. The majority of lesions (75%) remained the same size or grew by <2 mm in diameter. An increase in lesion size was associated with change in the total number of colours and structures (χ 2 = 14·3, P = 0·027) at follow-up. Conclusions: While their diameter changed minimally over time, most SGM became more disorganized, revealed loss of network in favour of structureless areas, and developed new colours.

Original languageEnglish
Pages (from-to)1213-1220
Number of pages8
JournalBritish Journal of Dermatology
Volume166
Issue number6
DOIs
Publication statusPublished - Jun 2012

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Melanoma
Color
Dermoscopy
Growth

ASJC Scopus subject areas

  • Dermatology

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Terushkin, V., Dusza, S. W., Scope, A., Argenziano, G., Bahadoran, P., Cowell, L., ... Marghoob, A. A. (2012). Changes observed in slow-growing melanomas during long-term dermoscopic monitoring. British Journal of Dermatology, 166(6), 1213-1220. https://doi.org/10.1111/j.1365-2133.2012.10846.x

Changes observed in slow-growing melanomas during long-term dermoscopic monitoring. / Terushkin, V.; Dusza, S. W.; Scope, A.; Argenziano, G.; Bahadoran, P.; Cowell, L.; De Giorgi, V.; Ferrara, G.; Kittler, H.; Malvehy, J.; Menzies, S.; Piccolo, D.; Puig, S.; Rubegni, P.; Stanganelli, I.; Thomas, L.; Zalaudek, I.; Marghoob, A. A.

In: British Journal of Dermatology, Vol. 166, No. 6, 06.2012, p. 1213-1220.

Research output: Contribution to journalArticle

Terushkin, V, Dusza, SW, Scope, A, Argenziano, G, Bahadoran, P, Cowell, L, De Giorgi, V, Ferrara, G, Kittler, H, Malvehy, J, Menzies, S, Piccolo, D, Puig, S, Rubegni, P, Stanganelli, I, Thomas, L, Zalaudek, I & Marghoob, AA 2012, 'Changes observed in slow-growing melanomas during long-term dermoscopic monitoring', British Journal of Dermatology, vol. 166, no. 6, pp. 1213-1220. https://doi.org/10.1111/j.1365-2133.2012.10846.x
Terushkin, V. ; Dusza, S. W. ; Scope, A. ; Argenziano, G. ; Bahadoran, P. ; Cowell, L. ; De Giorgi, V. ; Ferrara, G. ; Kittler, H. ; Malvehy, J. ; Menzies, S. ; Piccolo, D. ; Puig, S. ; Rubegni, P. ; Stanganelli, I. ; Thomas, L. ; Zalaudek, I. ; Marghoob, A. A. / Changes observed in slow-growing melanomas during long-term dermoscopic monitoring. In: British Journal of Dermatology. 2012 ; Vol. 166, No. 6. pp. 1213-1220.
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abstract = "Background: Melanomas vary in growth rate from rapidly developing nodular melanomas to slow-growing melanomas (SGM) that hardly change over years. Objectives: To evaluate longitudinal changes in dermoscopic findings of SGM. Methods We retrospectively analysed a dermoscopic image dataset from 15 pigmented lesion clinics, of SGM that were followed sequentially by digital dermoscopy for at least 1 year. We evaluated baseline and follow-up images for changes in global pattern, organization, colours, structure and size. Results: Our series consisted of 92 SGM. On follow-up, these melanomas developed the following dermoscopic findings: more homogeneous and less reticular global dermoscopic pattern; more frequent disorganization of pattern (baseline, 67{\%} vs. follow-up, 79{\%}); decreased prominence of light brown colour, increased prominence of dark brown colour, and increased frequency of the colours red, white, grey, blue and black (baseline: 29{\%}, 3{\%}, 18{\%}, 6{\%} and 33{\%} vs. follow-up: 41{\%}, 10{\%}, 31{\%}, 13{\%} and 45{\%}, respectively); decrease in prominence of dermoscopic structure of pigmented network, with a concomitant increase in prominence of structureless areas; and increased prominence or new appearance of melanoma-specific dermoscopic structures, including negative network, blue-white structures and blotches. The majority of lesions (75{\%}) remained the same size or grew by <2 mm in diameter. An increase in lesion size was associated with change in the total number of colours and structures (χ 2 = 14·3, P = 0·027) at follow-up. Conclusions: While their diameter changed minimally over time, most SGM became more disorganized, revealed loss of network in favour of structureless areas, and developed new colours.",
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AU - Dusza, S. W.

AU - Scope, A.

AU - Argenziano, G.

AU - Bahadoran, P.

AU - Cowell, L.

AU - De Giorgi, V.

AU - Ferrara, G.

AU - Kittler, H.

AU - Malvehy, J.

AU - Menzies, S.

AU - Piccolo, D.

AU - Puig, S.

AU - Rubegni, P.

AU - Stanganelli, I.

AU - Thomas, L.

AU - Zalaudek, I.

AU - Marghoob, A. A.

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N2 - Background: Melanomas vary in growth rate from rapidly developing nodular melanomas to slow-growing melanomas (SGM) that hardly change over years. Objectives: To evaluate longitudinal changes in dermoscopic findings of SGM. Methods We retrospectively analysed a dermoscopic image dataset from 15 pigmented lesion clinics, of SGM that were followed sequentially by digital dermoscopy for at least 1 year. We evaluated baseline and follow-up images for changes in global pattern, organization, colours, structure and size. Results: Our series consisted of 92 SGM. On follow-up, these melanomas developed the following dermoscopic findings: more homogeneous and less reticular global dermoscopic pattern; more frequent disorganization of pattern (baseline, 67% vs. follow-up, 79%); decreased prominence of light brown colour, increased prominence of dark brown colour, and increased frequency of the colours red, white, grey, blue and black (baseline: 29%, 3%, 18%, 6% and 33% vs. follow-up: 41%, 10%, 31%, 13% and 45%, respectively); decrease in prominence of dermoscopic structure of pigmented network, with a concomitant increase in prominence of structureless areas; and increased prominence or new appearance of melanoma-specific dermoscopic structures, including negative network, blue-white structures and blotches. The majority of lesions (75%) remained the same size or grew by <2 mm in diameter. An increase in lesion size was associated with change in the total number of colours and structures (χ 2 = 14·3, P = 0·027) at follow-up. Conclusions: While their diameter changed minimally over time, most SGM became more disorganized, revealed loss of network in favour of structureless areas, and developed new colours.

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