Changes of cine cerebrospinal fluid dynamics in patients with multiple sclerosis treated with percutaneous transluminal angioplasty: A case-control study

Robert Zivadinov, Christopher Magnano, Roberto Galeotti, Claudiu Schirda, Erica Menegatti, Bianca Weinstock-Guttman, Karen Marr, Ilaria Bartolomei, Jesper Hagemeier, Anna Maria Malagoni, David Hojnacki, Cheryl Kennedy, Ellen Carl, Clive Beggs, Fabrizio Salvi, Paolo Zamboni

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate characteristics of cine phase contrast-calculated cerebrospinal fluid (CSF) flow and velocity measures in patients with relapsing-remitting (RR) multiple sclerosis (MS) receiving standard medical treatment who had been diagnosed with chronic cerebrospinal venous insufficiency (CCSVI) and underwent percutaneous transluminal angioplasty (PTA). Materials and Methods: This case-controlled, magnetic resonance (MR) imaging-blinded study included 15 patients with RR MS who presented with significant stenoses (≥50% lumen reduction on catheter venography) in the azygous or internal jugular veins. Eight patients underwent PTA in addition to medical therapy immediately following baseline assessments (case group) and seven had delayed PTA after 6 months of medical therapy alone (control group). CSF flow and velocity measures were quantified over 32 phases of the cardiac cycle by a semiautomated method. Outcomes were compared between groups at baseline and at 6 and 12 months of the study by mixed-effect model analysis. Results: At baseline, no significant differences in CSF flow or velocity measures were detected between groups. At month 6, significant improvement in flow (P

Original languageEnglish
Pages (from-to)829-838
Number of pages10
JournalJournal of Vascular and Interventional Radiology
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2013

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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