TY - JOUR
T1 - Changes of cine cerebrospinal fluid dynamics in patients with multiple sclerosis treated with percutaneous transluminal angioplasty
T2 - A case-control study
AU - Zivadinov, Robert
AU - Magnano, Christopher
AU - Galeotti, Roberto
AU - Schirda, Claudiu
AU - Menegatti, Erica
AU - Weinstock-Guttman, Bianca
AU - Marr, Karen
AU - Bartolomei, Ilaria
AU - Hagemeier, Jesper
AU - Maria Malagoni, Anna
AU - Hojnacki, David
AU - Kennedy, Cheryl
AU - Carl, Ellen
AU - Beggs, Clive
AU - Salvi, Fabrizio
AU - Zamboni, Paolo
PY - 2013/6
Y1 - 2013/6
N2 - Purpose: To investigate characteristics of cine phase contrast-calculated cerebrospinal fluid (CSF) flow and velocity measures in patients with relapsing-remitting (RR) multiple sclerosis (MS) receiving standard medical treatment who had been diagnosed with chronic cerebrospinal venous insufficiency (CCSVI) and underwent percutaneous transluminal angioplasty (PTA). Materials and Methods: This case-controlled, magnetic resonance (MR) imaging-blinded study included 15 patients with RR MS who presented with significant stenoses (≥50% lumen reduction on catheter venography) in the azygous or internal jugular veins. Eight patients underwent PTA in addition to medical therapy immediately following baseline assessments (case group) and seven had delayed PTA after 6 months of medical therapy alone (control group). CSF flow and velocity measures were quantified over 32 phases of the cardiac cycle by a semiautomated method. Outcomes were compared between groups at baseline and at 6 and 12 months of the study by mixed-effect model analysis. Results: At baseline, no significant differences in CSF flow or velocity measures were detected between groups. At month 6, significant improvement in flow (P
AB - Purpose: To investigate characteristics of cine phase contrast-calculated cerebrospinal fluid (CSF) flow and velocity measures in patients with relapsing-remitting (RR) multiple sclerosis (MS) receiving standard medical treatment who had been diagnosed with chronic cerebrospinal venous insufficiency (CCSVI) and underwent percutaneous transluminal angioplasty (PTA). Materials and Methods: This case-controlled, magnetic resonance (MR) imaging-blinded study included 15 patients with RR MS who presented with significant stenoses (≥50% lumen reduction on catheter venography) in the azygous or internal jugular veins. Eight patients underwent PTA in addition to medical therapy immediately following baseline assessments (case group) and seven had delayed PTA after 6 months of medical therapy alone (control group). CSF flow and velocity measures were quantified over 32 phases of the cardiac cycle by a semiautomated method. Outcomes were compared between groups at baseline and at 6 and 12 months of the study by mixed-effect model analysis. Results: At baseline, no significant differences in CSF flow or velocity measures were detected between groups. At month 6, significant improvement in flow (P
UR - http://www.scopus.com/inward/record.url?scp=84878114408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878114408&partnerID=8YFLogxK
U2 - 10.1016/j.jvir.2013.01.490
DO - 10.1016/j.jvir.2013.01.490
M3 - Article
C2 - 23523158
AN - SCOPUS:84878114408
VL - 24
SP - 829
EP - 838
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
SN - 1051-0443
IS - 6
ER -