Changes of opioid modulation of the hypothalamo-pituitary-adrenal axis in patients with severe premenstrual syndrome

F. Facchinetti, L. Fioroni, E. Martignoni, G. Sances, A. Costa, A. R. Genazzani

Research output: Contribution to journalArticle

Abstract

To assess the function of the hypothalamus-pituitary-adrenal axis in patients with severe premenstrual syndrome (PMS) 28 patients and 14 asymptomatic controls were studied during the mid- to late-luteal phase of the menstrual cycle. The response of plasma cortisol to both high-dose naloxone and corticotropin-releasing hormone (CRH) was assessed. Naloxone stimulated a significant cortisol release in controls whereas it was otherwise almost absent in patients. CRH stimulated a greater release of cortisol in patients than in controls. Fifteen patients met criteria for either current anxiety and/or mood disorders. The cortisol secretion after both naloxone and CRH stimulations was similar for PMS patients with or without psychiatric disorders. These data indicate that endogenous opioids modulate the activity of the hypothalamus-pituitary-adrenal axis. Irrespective of the concomitant presence of menstrual migraine or psychiatric disorder, such control is altered in patients with severe PMS because of the possible hyposensitivity of opiate receptors. The hyperresponsiveness to CRH may be the consequence of the reduced inhibition that endogenous opioids tonically exert on HPA axis.

Original languageEnglish
Pages (from-to)418-422
Number of pages5
JournalPsychosomatic Medicine
Volume56
Issue number5
Publication statusPublished - 1994

Fingerprint

Premenstrual Syndrome
Opioid Analgesics
Corticotropin-Releasing Hormone
Hydrocortisone
Naloxone
Hypothalamus
Psychiatry
Luteal Phase
Opioid Receptors
Anxiety Disorders
Migraine Disorders
Mood Disorders

Keywords

  • cortisol
  • CRH
  • hypothalamus- pituitary-adrenal axis
  • naloxone
  • Opioids
  • premenstrual syndrome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Changes of opioid modulation of the hypothalamo-pituitary-adrenal axis in patients with severe premenstrual syndrome. / Facchinetti, F.; Fioroni, L.; Martignoni, E.; Sances, G.; Costa, A.; Genazzani, A. R.

In: Psychosomatic Medicine, Vol. 56, No. 5, 1994, p. 418-422.

Research output: Contribution to journalArticle

Facchinetti, F. ; Fioroni, L. ; Martignoni, E. ; Sances, G. ; Costa, A. ; Genazzani, A. R. / Changes of opioid modulation of the hypothalamo-pituitary-adrenal axis in patients with severe premenstrual syndrome. In: Psychosomatic Medicine. 1994 ; Vol. 56, No. 5. pp. 418-422.
@article{85920a553738408f93fddb7936d1ac66,
title = "Changes of opioid modulation of the hypothalamo-pituitary-adrenal axis in patients with severe premenstrual syndrome",
abstract = "To assess the function of the hypothalamus-pituitary-adrenal axis in patients with severe premenstrual syndrome (PMS) 28 patients and 14 asymptomatic controls were studied during the mid- to late-luteal phase of the menstrual cycle. The response of plasma cortisol to both high-dose naloxone and corticotropin-releasing hormone (CRH) was assessed. Naloxone stimulated a significant cortisol release in controls whereas it was otherwise almost absent in patients. CRH stimulated a greater release of cortisol in patients than in controls. Fifteen patients met criteria for either current anxiety and/or mood disorders. The cortisol secretion after both naloxone and CRH stimulations was similar for PMS patients with or without psychiatric disorders. These data indicate that endogenous opioids modulate the activity of the hypothalamus-pituitary-adrenal axis. Irrespective of the concomitant presence of menstrual migraine or psychiatric disorder, such control is altered in patients with severe PMS because of the possible hyposensitivity of opiate receptors. The hyperresponsiveness to CRH may be the consequence of the reduced inhibition that endogenous opioids tonically exert on HPA axis.",
keywords = "cortisol, CRH, hypothalamus- pituitary-adrenal axis, naloxone, Opioids, premenstrual syndrome",
author = "F. Facchinetti and L. Fioroni and E. Martignoni and G. Sances and A. Costa and Genazzani, {A. R.}",
year = "1994",
language = "English",
volume = "56",
pages = "418--422",
journal = "Psychosomatic Medicine",
issn = "0033-3174",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Changes of opioid modulation of the hypothalamo-pituitary-adrenal axis in patients with severe premenstrual syndrome

AU - Facchinetti, F.

AU - Fioroni, L.

AU - Martignoni, E.

AU - Sances, G.

AU - Costa, A.

AU - Genazzani, A. R.

PY - 1994

Y1 - 1994

N2 - To assess the function of the hypothalamus-pituitary-adrenal axis in patients with severe premenstrual syndrome (PMS) 28 patients and 14 asymptomatic controls were studied during the mid- to late-luteal phase of the menstrual cycle. The response of plasma cortisol to both high-dose naloxone and corticotropin-releasing hormone (CRH) was assessed. Naloxone stimulated a significant cortisol release in controls whereas it was otherwise almost absent in patients. CRH stimulated a greater release of cortisol in patients than in controls. Fifteen patients met criteria for either current anxiety and/or mood disorders. The cortisol secretion after both naloxone and CRH stimulations was similar for PMS patients with or without psychiatric disorders. These data indicate that endogenous opioids modulate the activity of the hypothalamus-pituitary-adrenal axis. Irrespective of the concomitant presence of menstrual migraine or psychiatric disorder, such control is altered in patients with severe PMS because of the possible hyposensitivity of opiate receptors. The hyperresponsiveness to CRH may be the consequence of the reduced inhibition that endogenous opioids tonically exert on HPA axis.

AB - To assess the function of the hypothalamus-pituitary-adrenal axis in patients with severe premenstrual syndrome (PMS) 28 patients and 14 asymptomatic controls were studied during the mid- to late-luteal phase of the menstrual cycle. The response of plasma cortisol to both high-dose naloxone and corticotropin-releasing hormone (CRH) was assessed. Naloxone stimulated a significant cortisol release in controls whereas it was otherwise almost absent in patients. CRH stimulated a greater release of cortisol in patients than in controls. Fifteen patients met criteria for either current anxiety and/or mood disorders. The cortisol secretion after both naloxone and CRH stimulations was similar for PMS patients with or without psychiatric disorders. These data indicate that endogenous opioids modulate the activity of the hypothalamus-pituitary-adrenal axis. Irrespective of the concomitant presence of menstrual migraine or psychiatric disorder, such control is altered in patients with severe PMS because of the possible hyposensitivity of opiate receptors. The hyperresponsiveness to CRH may be the consequence of the reduced inhibition that endogenous opioids tonically exert on HPA axis.

KW - cortisol

KW - CRH

KW - hypothalamus- pituitary-adrenal axis

KW - naloxone

KW - Opioids

KW - premenstrual syndrome

UR - http://www.scopus.com/inward/record.url?scp=0028659785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028659785&partnerID=8YFLogxK

M3 - Article

C2 - 7809341

AN - SCOPUS:0028659785

VL - 56

SP - 418

EP - 422

JO - Psychosomatic Medicine

JF - Psychosomatic Medicine

SN - 0033-3174

IS - 5

ER -