Alterazioni della RMN cerebrale nei pazienti affetti da emicrania e cefalea di tipo tensivo

Translated title of the contribution: Changes on cerebral MRI in patients with migraine and tension headache

Domenico Intiso, Giuseppe Rinaldi, Raffaele Cioffi, Pietro Di Viesti, Paola Crociani, Salvatore Nasuto, Francesco Apollo, Pasquale Simone, Pietro Tonali

Research output: Contribution to journalArticlepeer-review


Focal lesions of increased signal within cerebral white matter on T2- weighted MR images have been reported in migraine patients. The percentage of this finding ranged from 12 to 47%, varying broadly. Furthermore the origin and the nature of cerebral lesions remain uncertain. We enrolled 80 (58F, 22M, mean age 33.8±11.1 years) consecutive migraine patients (MP) to ascertain MRI focal cerebral hyperintensity. Fifty (34F, 16M, mean age 37.5±16.8) tension headache patients (THP) were included as control group. Antiphospholipid antibodies (ACA, LAC), protein C and S, antithrombin III were titrated in patients who showed MRI cerebral focal hyperintensity lesions in both groups. Furthermore they underwent to evoked potentials (VEP, SEP, BAEP) and carotid ultrasonography examinations. Twenty-two (27.5%) and 15 (30%) patients showed MRI lesions in migraine and tension-type headache group, respectively. One female migrainous patient showed a little aneurism of the left middle cerebral artery. No alteration of coagulation parameters and instrumental examinations as well as serum antiphospholipid antibodies presence were detected in MP and TH patients with MRI focal cerebral hyperintensity. However, these patients, particularly those with tension- type headache, were significantly older and more hypertensive than patients without cerebral lesions. Furthermore, THP showed more carotid intima thickness. Neuroimaging finding of focal high signal within cerebral white matter is fairly common in migraine and tension-type headache patients but it is not produced by derangement of coagulation parameters. Risk factors for cerebrovascular disease such as hypertension, dyslipidemia and age could account for this finding in older patients.

Translated title of the contributionChanges on cerebral MRI in patients with migraine and tension headache
Original languageItalian
Pages (from-to)3-8
Number of pages6
JournalConfinia Cephalalgica
Issue number1
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Clinical Neurology


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