Changing Concepts of Cirrhotic Coagulopathy

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Abstract

The state of clinical art of the coagulopathy of cirrhosis changed considerably over the last decade. Until 2005, cirrhosis was considered as the epitome of the hemorrhagic coagulopathies and the abnormal hemostasis tests associated with the disease were corrected with infusion of fresh frozen plasma or platelets to minimize the risk of bleeding. Since that time, a great deal of work has been done and there is now a change of paradigm. The prothrombin time once considered as an isolated measure of bleeding risk was rejected, and cirrhosis shifted from a purely hemorrhagic construct to a mixed and thrombosis-prone paradigm. In this article we examine the interesting history of how these conceptual changes came about.Am J Gastroenterol advance online publication, 1 November 2016; doi:10.1038/ajg.2016.498.

Original languageEnglish
Pages (from-to)274-281
JournalAmerican Journal of Gastroenterology
Volume112
Issue number2
DOIs
Publication statusPublished - 2017

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Fibrosis
Hemorrhage
Prothrombin Time
Art
Hemostasis
Publications
Thrombosis
Blood Platelets
History

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Changing Concepts of Cirrhotic Coagulopathy. / Tripodi, Armando; Primignani, Massimo; Mannucci, Pier M.; Caldwell, Stephen H.

In: American Journal of Gastroenterology, Vol. 112, No. 2, 2017, p. 274-281.

Research output: Contribution to journalArticle

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