Changing epidemiology of Infant Meningococcal Disease after the introduction of meningococcal serogroup C vaccine in Italy, 2006-2014

P. Stefanelli, C. Fazio, A. Neri, S. Boros, G. Renna, M. G. Pompa, Fortunato P. D'Ancona, Maria Grazia Caporali, Richard Aschbacher, Anna Maria Barbui, Maria Chironna, Laura Daprai, Anna Di Taranto, Maria Laura Garlaschi, Maria Paola Landini, Paolo Lanzafame, Antonella Mencacci, Lucia Rossi, Iolanda Santino, Christine SpitalerCarlo Tascini, Caterina Vocale

Research output: Contribution to journalArticle

Abstract

Background: In Italy, the incidence of Invasive Meningococcal Disease (IMD) was around 0.28 per 100,000 over the last years. Since the risk IMD is usually high among infants aged less than 1 year, we decided to evaluate the trend of IMD cases reported between 2006 and 2014 in this age group. In particular, the study aim was to describe the main characteristics of IMD cases in infants following the introduction of MCC vaccine (2005) and to estimate the number of cases which are potentially preventable through early vaccination. Methods: The National Surveillance System of Bacterial Meningitis was established in 1994 and in 2007 was extended to all invasive bacterial diseases. Clinical data and isolates and/or clinical samples are collected from hospitalized patients throughout the country. IMD cases are reported by clinicians to the local health authorities, and samples are sent to the Reference Laboratory at the Istituto Superiore di Sanità for further characterization and storage at -80 °C. In particular, serogroup identification is obtained by agglutination with commercial antisera or by multiplex PCR. Results: The annual incidence for infants

Original languageEnglish
Pages (from-to)3678-3681
Number of pages4
JournalVaccine
Volume33
Issue number31
DOIs
Publication statusPublished - Jul 17 2015

Keywords

  • IMD
  • Infant
  • Neisseria meningitidis
  • Surveillance
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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    Stefanelli, P., Fazio, C., Neri, A., Boros, S., Renna, G., Pompa, M. G., D'Ancona, F. P., Caporali, M. G., Aschbacher, R., Barbui, A. M., Chironna, M., Daprai, L., Taranto, A. D., Garlaschi, M. L., Landini, M. P., Lanzafame, P., Mencacci, A., Rossi, L., Santino, I., ... Vocale, C. (2015). Changing epidemiology of Infant Meningococcal Disease after the introduction of meningococcal serogroup C vaccine in Italy, 2006-2014. Vaccine, 33(31), 3678-3681. https://doi.org/10.1016/j.vaccine.2015.06.032