Changing pattern of presentation in monoclonal gammopathy of undetermined significance: A single-center experience with 1400 patients

Marzia Varettoni; Alessandro Corso; Federica Cocito; Silvia Mangiacavalli; Cristiana Pascutto; Patrizia Zappasodi; Gianmatteo Pica; Mario Lazzarino

doi:10.1097/MD.0b013e3181e763be

Changing pattern of presentation in monoclonal gammopathy of undetermined significance: A single-center experience with 1400 patients

Marzia Varettoni, Alessandro Corso, Federica Cocito, Silvia Mangiacavalli, Cristiana Pascutto, Patrizia Zappasodi, Gianmatteo Pica, Mario Lazzarino

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article

Abstract

To assess whether the pattern of presentation and the outcome of monoclonal gammopathy of undetermined significance (MGUS) have changed over the last 3 decades, we evaluated 1400 patients, divided into 3 groups: group I (1975-1987), group II (1988-1997), and group III (1998-2007).We observed a significant increase in age (p = 0.001), IgM and biclonal MGUS (p = 0.003), hemoglobin (p <0.0001), and albumin (p = 0.0001), and a significant reduction of monoclonal (M)-protein concentration (p <0.0001), percentage of bone marrow plasma cells (p <0.0001), and β2-microglobulin (p = 0.0001) over the 3 decades. The proportion of patients with M-protein

Original language	English
Pages (from-to)	211-216
Number of pages	6
Journal	Medicine (United States)
Volume	89
Issue number	4
DOIs	https://doi.org/10.1097/MD.0b013e3181e763be
Publication status	Published - Jul 2010

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Medicine(all)

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Varettoni, M., Corso, A., Cocito, F., Mangiacavalli, S., Pascutto, C., Zappasodi, P., Pica, G., & Lazzarino, M. (2010). Changing pattern of presentation in monoclonal gammopathy of undetermined significance: A single-center experience with 1400 patients. Medicine (United States), 89(4), 211-216. https://doi.org/10.1097/MD.0b013e3181e763be

Changing pattern of presentation in monoclonal gammopathy of undetermined significance : A single-center experience with 1400 patients. / Varettoni, Marzia ; Corso, Alessandro; Cocito, Federica; Mangiacavalli, Silvia; Pascutto, Cristiana; Zappasodi, Patrizia; Pica, Gianmatteo; Lazzarino, Mario.

In: Medicine (United States), Vol. 89, No. 4, 07.2010, p. 211-216.

Research output: Contribution to journal › Article

Varettoni, Marzia ; Corso, Alessandro ; Cocito, Federica ; Mangiacavalli, Silvia ; Pascutto, Cristiana ; Zappasodi, Patrizia ; Pica, Gianmatteo ; Lazzarino, Mario. / Changing pattern of presentation in monoclonal gammopathy of undetermined significance : A single-center experience with 1400 patients. In: Medicine (United States). 2010 ; Vol. 89, No. 4. pp. 211-216.

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10.1097/MD.0b013e3181e763be