Changing pattern of presentation in monoclonal gammopathy of undetermined significance: A single-center experience with 1400 patients

Marzia Varettoni, Alessandro Corso, Federica Cocito, Silvia Mangiacavalli, Cristiana Pascutto, Patrizia Zappasodi, Gianmatteo Pica, Mario Lazzarino

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To assess whether the pattern of presentation and the outcome of monoclonal gammopathy of undetermined significance (MGUS) have changed over the last 3 decades, we evaluated 1400 patients, divided into 3 groups: group I (1975-1987), group II (1988-1997), and group III (1998-2007).We observed a significant increase in age (p = 0.001), IgM and biclonal MGUS (p = 0.003), hemoglobin (p <0.0001), and albumin (p = 0.0001), and a significant reduction of monoclonal (M)-protein concentration (p <0.0001), percentage of bone marrow plasma cells (p <0.0001), and β2-microglobulin (p = 0.0001) over the 3 decades. The proportion of patients with M-protein

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalMedicine (United States)
Issue number4
Publication statusPublished - Jul 2010


ASJC Scopus subject areas

  • Medicine(all)

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