Abstract
To assess whether the pattern of presentation and the outcome of monoclonal gammopathy of undetermined significance (MGUS) have changed over the last 3 decades, we evaluated 1400 patients, divided into 3 groups: group I (1975-1987), group II (1988-1997), and group III (1998-2007).We observed a significant increase in age (p = 0.001), IgM and biclonal MGUS (p = 0.003), hemoglobin (p <0.0001), and albumin (p = 0.0001), and a significant reduction of monoclonal (M)-protein concentration (p <0.0001), percentage of bone marrow plasma cells (p <0.0001), and β2-microglobulin (p = 0.0001) over the 3 decades. The proportion of patients with M-protein
| Original language | English |
|---|---|
| Pages (from-to) | 211-216 |
| Number of pages | 6 |
| Journal | Medicine (United States) |
| Volume | 89 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2010 |
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Changing pattern of presentation in monoclonal gammopathy of undetermined significance : A single-center experience with 1400 patients. / Varettoni, Marzia; Corso, Alessandro; Cocito, Federica; Mangiacavalli, Silvia; Pascutto, Cristiana; Zappasodi, Patrizia; Pica, Gianmatteo; Lazzarino, Mario.
In: Medicine (United States), Vol. 89, No. 4, 07.2010, p. 211-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changing pattern of presentation in monoclonal gammopathy of undetermined significance
T2 - A single-center experience with 1400 patients
AU - Varettoni, Marzia
AU - Corso, Alessandro
AU - Cocito, Federica
AU - Mangiacavalli, Silvia
AU - Pascutto, Cristiana
AU - Zappasodi, Patrizia
AU - Pica, Gianmatteo
AU - Lazzarino, Mario
PY - 2010/7
Y1 - 2010/7
N2 - To assess whether the pattern of presentation and the outcome of monoclonal gammopathy of undetermined significance (MGUS) have changed over the last 3 decades, we evaluated 1400 patients, divided into 3 groups: group I (1975-1987), group II (1988-1997), and group III (1998-2007).We observed a significant increase in age (p = 0.001), IgM and biclonal MGUS (p = 0.003), hemoglobin (p <0.0001), and albumin (p = 0.0001), and a significant reduction of monoclonal (M)-protein concentration (p <0.0001), percentage of bone marrow plasma cells (p <0.0001), and β2-microglobulin (p = 0.0001) over the 3 decades. The proportion of patients with M-protein
AB - To assess whether the pattern of presentation and the outcome of monoclonal gammopathy of undetermined significance (MGUS) have changed over the last 3 decades, we evaluated 1400 patients, divided into 3 groups: group I (1975-1987), group II (1988-1997), and group III (1998-2007).We observed a significant increase in age (p = 0.001), IgM and biclonal MGUS (p = 0.003), hemoglobin (p <0.0001), and albumin (p = 0.0001), and a significant reduction of monoclonal (M)-protein concentration (p <0.0001), percentage of bone marrow plasma cells (p <0.0001), and β2-microglobulin (p = 0.0001) over the 3 decades. The proportion of patients with M-protein
UR - http://www.scopus.com/inward/record.url?scp=77954712591&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954712591&partnerID=8YFLogxK
U2 - 10.1097/MD.0b013e3181e763be
DO - 10.1097/MD.0b013e3181e763be
M3 - Article
C2 - 20616660
AN - SCOPUS:77954712591
VL - 89
SP - 211
EP - 216
JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
SN - 0025-7974
IS - 4
ER -