Changing patterns in clinical-histological presentation and renal outcome over the last five decades in a cohort of 499 patients with lupus nephritis

Gabriella Moroni, Paolo Gilles Vercelloni, Silvana Quaglini, Mariele Gatto, Davide Gianfreda, Lucia Sacchi, Francesca Raffiotta, Margherita Zen, Gloria Costantini, Maria Letizia Urban, Federico Pieruzzi, Piergiorgio Messa, Augusto Vaglio, Renato Alberto Sinico, Andrea Doria

Research output: Contribution to journalArticle

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Abstract

Objectives: To evaluate changes in demographic, clinical and histological presentation, and prognosis of lupus nephritis (LN) over time. Patients and methods: We studied a multicentre cohort of 499 patients diagnosed with LN from 1970 to 2016. The 46-year follow-up was subdivided into three periods (P): P1 1970-1985, P2 1986-2001 and P3 2002-2016, and patients accordingly grouped based on the year of LN diagnosis. Predictors of patient and renal survival were investigated by univariate and multivariate proportional hazards Cox regression analyses. Survival curves were compared using the log-rank test. Results: A progressive increase in patient age at the time of LN diagnosis (p<0.0001) and a longer time between systemic lupus erythematosus onset and LN occurrence (p<0.0001) was observed from 1970 to 2016. During the same period, the frequency of renal insufficiency at the time of LN presentation progressively decreased (p<0.0001) and that of isolated urinary abnormalities increased (p<0.0001). No changes in histological class and activity index were observed, while chronicity index significantly decreased from 1970 to 2016 (p=0.023). Survival without end-stage renal disease (ESRD) was 87% in P1, 94% in P2% and 99% in P3 at 10 years, 80% in P1 and 90% in P2 at 20 years (p=0.0019). At multivariate analysis, male gender, arterial hypertension, absence of maintenance immunosuppressive therapy, increased serum creatinine, and high activity and chronicity index were independent predictors of ESRD. Conclusions: Clinical presentation of LN has become less severe in the last years, leading to a better long-term renal survival.

Original languageEnglish
Pages (from-to)1318-1325
JournalAnnals of the Rheumatic Diseases
Volume77
Issue number9
DOIs
Publication statusPublished - 2018

Fingerprint

Lupus Nephritis
Kidney
Immunosuppressive Agents
Creatinine
Hazards
Chronic Kidney Failure
Survival
Systemic Lupus Erythematosus
Renal Insufficiency
Multivariate Analysis
Regression Analysis
Maintenance
Demography
Hypertension
Serum

Keywords

  • lupus nephritis
  • research outcomes
  • systemic lupus erythematosus
  • treatment

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Changing patterns in clinical-histological presentation and renal outcome over the last five decades in a cohort of 499 patients with lupus nephritis. / Moroni, Gabriella; Vercelloni, Paolo Gilles; Quaglini, Silvana; Gatto, Mariele; Gianfreda, Davide; Sacchi, Lucia; Raffiotta, Francesca; Zen, Margherita; Costantini, Gloria; Urban, Maria Letizia; Pieruzzi, Federico; Messa, Piergiorgio; Vaglio, Augusto; Sinico, Renato Alberto; Doria, Andrea.

In: Annals of the Rheumatic Diseases, Vol. 77, No. 9, 2018, p. 1318-1325.

Research output: Contribution to journalArticle

Moroni, G, Vercelloni, PG, Quaglini, S, Gatto, M, Gianfreda, D, Sacchi, L, Raffiotta, F, Zen, M, Costantini, G, Urban, ML, Pieruzzi, F, Messa, P, Vaglio, A, Sinico, RA & Doria, A 2018, 'Changing patterns in clinical-histological presentation and renal outcome over the last five decades in a cohort of 499 patients with lupus nephritis', Annals of the Rheumatic Diseases, vol. 77, no. 9, pp. 1318-1325. https://doi.org/10.1136/annrheumdis-2017-212732
Moroni, Gabriella ; Vercelloni, Paolo Gilles ; Quaglini, Silvana ; Gatto, Mariele ; Gianfreda, Davide ; Sacchi, Lucia ; Raffiotta, Francesca ; Zen, Margherita ; Costantini, Gloria ; Urban, Maria Letizia ; Pieruzzi, Federico ; Messa, Piergiorgio ; Vaglio, Augusto ; Sinico, Renato Alberto ; Doria, Andrea. / Changing patterns in clinical-histological presentation and renal outcome over the last five decades in a cohort of 499 patients with lupus nephritis. In: Annals of the Rheumatic Diseases. 2018 ; Vol. 77, No. 9. pp. 1318-1325.
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abstract = "Objectives: To evaluate changes in demographic, clinical and histological presentation, and prognosis of lupus nephritis (LN) over time. Patients and methods: We studied a multicentre cohort of 499 patients diagnosed with LN from 1970 to 2016. The 46-year follow-up was subdivided into three periods (P): P1 1970-1985, P2 1986-2001 and P3 2002-2016, and patients accordingly grouped based on the year of LN diagnosis. Predictors of patient and renal survival were investigated by univariate and multivariate proportional hazards Cox regression analyses. Survival curves were compared using the log-rank test. Results: A progressive increase in patient age at the time of LN diagnosis (p<0.0001) and a longer time between systemic lupus erythematosus onset and LN occurrence (p<0.0001) was observed from 1970 to 2016. During the same period, the frequency of renal insufficiency at the time of LN presentation progressively decreased (p<0.0001) and that of isolated urinary abnormalities increased (p<0.0001). No changes in histological class and activity index were observed, while chronicity index significantly decreased from 1970 to 2016 (p=0.023). Survival without end-stage renal disease (ESRD) was 87{\%} in P1, 94{\%} in P2{\%} and 99{\%} in P3 at 10 years, 80{\%} in P1 and 90{\%} in P2 at 20 years (p=0.0019). At multivariate analysis, male gender, arterial hypertension, absence of maintenance immunosuppressive therapy, increased serum creatinine, and high activity and chronicity index were independent predictors of ESRD. Conclusions: Clinical presentation of LN has become less severe in the last years, leading to a better long-term renal survival.",
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T1 - Changing patterns in clinical-histological presentation and renal outcome over the last five decades in a cohort of 499 patients with lupus nephritis

AU - Moroni, Gabriella

AU - Vercelloni, Paolo Gilles

AU - Quaglini, Silvana

AU - Gatto, Mariele

AU - Gianfreda, Davide

AU - Sacchi, Lucia

AU - Raffiotta, Francesca

AU - Zen, Margherita

AU - Costantini, Gloria

AU - Urban, Maria Letizia

AU - Pieruzzi, Federico

AU - Messa, Piergiorgio

AU - Vaglio, Augusto

AU - Sinico, Renato Alberto

AU - Doria, Andrea

PY - 2018

Y1 - 2018

N2 - Objectives: To evaluate changes in demographic, clinical and histological presentation, and prognosis of lupus nephritis (LN) over time. Patients and methods: We studied a multicentre cohort of 499 patients diagnosed with LN from 1970 to 2016. The 46-year follow-up was subdivided into three periods (P): P1 1970-1985, P2 1986-2001 and P3 2002-2016, and patients accordingly grouped based on the year of LN diagnosis. Predictors of patient and renal survival were investigated by univariate and multivariate proportional hazards Cox regression analyses. Survival curves were compared using the log-rank test. Results: A progressive increase in patient age at the time of LN diagnosis (p<0.0001) and a longer time between systemic lupus erythematosus onset and LN occurrence (p<0.0001) was observed from 1970 to 2016. During the same period, the frequency of renal insufficiency at the time of LN presentation progressively decreased (p<0.0001) and that of isolated urinary abnormalities increased (p<0.0001). No changes in histological class and activity index were observed, while chronicity index significantly decreased from 1970 to 2016 (p=0.023). Survival without end-stage renal disease (ESRD) was 87% in P1, 94% in P2% and 99% in P3 at 10 years, 80% in P1 and 90% in P2 at 20 years (p=0.0019). At multivariate analysis, male gender, arterial hypertension, absence of maintenance immunosuppressive therapy, increased serum creatinine, and high activity and chronicity index were independent predictors of ESRD. Conclusions: Clinical presentation of LN has become less severe in the last years, leading to a better long-term renal survival.

AB - Objectives: To evaluate changes in demographic, clinical and histological presentation, and prognosis of lupus nephritis (LN) over time. Patients and methods: We studied a multicentre cohort of 499 patients diagnosed with LN from 1970 to 2016. The 46-year follow-up was subdivided into three periods (P): P1 1970-1985, P2 1986-2001 and P3 2002-2016, and patients accordingly grouped based on the year of LN diagnosis. Predictors of patient and renal survival were investigated by univariate and multivariate proportional hazards Cox regression analyses. Survival curves were compared using the log-rank test. Results: A progressive increase in patient age at the time of LN diagnosis (p<0.0001) and a longer time between systemic lupus erythematosus onset and LN occurrence (p<0.0001) was observed from 1970 to 2016. During the same period, the frequency of renal insufficiency at the time of LN presentation progressively decreased (p<0.0001) and that of isolated urinary abnormalities increased (p<0.0001). No changes in histological class and activity index were observed, while chronicity index significantly decreased from 1970 to 2016 (p=0.023). Survival without end-stage renal disease (ESRD) was 87% in P1, 94% in P2% and 99% in P3 at 10 years, 80% in P1 and 90% in P2 at 20 years (p=0.0019). At multivariate analysis, male gender, arterial hypertension, absence of maintenance immunosuppressive therapy, increased serum creatinine, and high activity and chronicity index were independent predictors of ESRD. Conclusions: Clinical presentation of LN has become less severe in the last years, leading to a better long-term renal survival.

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KW - systemic lupus erythematosus

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