Our study investigated the evolving patterns of prescription of calcium channel blocking agents for patients with acute myocardial infarction who were studied in a series of three large successive trials conducted during the last decade. We also assessed current determinants of the use of calcium antagonists for postinfarction patients. In the three trials, a progressive and highly significant decrease in the prescription of these drugs for patients at hospital discharge was evident (from 47.2% to 35.1% to 19.0%); this decrease was more marked for nifedipine and verapamil than for diltiazem. Postinfarction angina, reinfarction, and a history of hypertension were associated with a greater use of calcium antagonists. The increasing use of beta blocking agents at discharge was a major independent negative determinant for prescribing calcium channel blocking agents. These agents are now given to postinfarction patients almost exclusively when a specific indication such as hypertension or angina is present.
|Number of pages||7|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine