Changing patterns in the postinfarction use of calcium antagonists

G. Zuanetti, R. Latini, A. P. Maggioni

Research output: Contribution to journalArticlepeer-review


Our study investigated the evolving patterns of prescription of calcium channel blocking agents for patients with acute myocardial infarction who were studied in a series of three large successive trials conducted during the last decade. We also assessed current determinants of the use of calcium antagonists for postinfarction patients. In the three trials, a progressive and highly significant decrease in the prescription of these drugs for patients at hospital discharge was evident (from 47.2% to 35.1% to 19.0%); this decrease was more marked for nifedipine and verapamil than for diltiazem. Postinfarction angina, reinfarction, and a history of hypertension were associated with a greater use of calcium antagonists. The increasing use of beta blocking agents at discharge was a major independent negative determinant for prescribing calcium channel blocking agents. These agents are now given to postinfarction patients almost exclusively when a specific indication such as hypertension or angina is present.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalCardiology Review
Issue number3
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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