TY - JOUR
T1 - Changing the metabolic profile by large-volume liposuction
T2 - A clinical study conducted with 123 obese women
AU - D'Andrea, Francesco
AU - Grella, Roberto
AU - Rizzo, Maria Rosaria
AU - Grella, Elisa
AU - Grella, Rodolfo
AU - Nicoletti, Gianfranco
AU - Barbieri, Michelangela
AU - Paolisso, Giuseppe
PY - 2005/12
Y1 - 2005/12
N2 - Adipose tissue is a metabolically active tissue. The hypertrophic fat cells of obese patients produce increased quantities of leptin and tumor necrosis factor-α (TNF-α) and are less sensitive to insulin. This study aimed to determine whether aspirating large amounts of these subcutaneous fat cells by large-volume liposuction (LVL), could change the metabolic profile in 123 obese women. All the patients had a main central body fat distribution (waist-hip ratio, 0.91 ± 0.01) and a body mass index of 32.8 ± 0.8 kg/m). They were studied for 90 days after LVL to determine their changes in insulin sensitivity, resting metabolic rate, serum adipocytokines, and inflammatory marker levels. During 3 months of follow-up evaluation, LVL resulted in a significantly improved insulin sensitivity, resting metabolic rate, serum adipocytokines, and inflammatory marker levels. Such parameters correlate with a decrease in fat mass and waist-hip ratio. Interestingly, no significant changes were seen between the first (21 days) and second (90 days) metabolic determinations after LVL. However, these findings, confirm other preliminary data published previously, and could change the actual role of LVL in the multidisciplinary treatment of obesity.
AB - Adipose tissue is a metabolically active tissue. The hypertrophic fat cells of obese patients produce increased quantities of leptin and tumor necrosis factor-α (TNF-α) and are less sensitive to insulin. This study aimed to determine whether aspirating large amounts of these subcutaneous fat cells by large-volume liposuction (LVL), could change the metabolic profile in 123 obese women. All the patients had a main central body fat distribution (waist-hip ratio, 0.91 ± 0.01) and a body mass index of 32.8 ± 0.8 kg/m). They were studied for 90 days after LVL to determine their changes in insulin sensitivity, resting metabolic rate, serum adipocytokines, and inflammatory marker levels. During 3 months of follow-up evaluation, LVL resulted in a significantly improved insulin sensitivity, resting metabolic rate, serum adipocytokines, and inflammatory marker levels. Such parameters correlate with a decrease in fat mass and waist-hip ratio. Interestingly, no significant changes were seen between the first (21 days) and second (90 days) metabolic determinations after LVL. However, these findings, confirm other preliminary data published previously, and could change the actual role of LVL in the multidisciplinary treatment of obesity.
KW - Adipocytokines
KW - Hypertrophic fat cells
KW - Inflammatory state
KW - Insulin resistance large-volume liposuction
KW - Leptin
KW - Obesity
KW - RMR
UR - http://www.scopus.com/inward/record.url?scp=29744455324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29744455324&partnerID=8YFLogxK
U2 - 10.1007/s00266-005-0089-x
DO - 10.1007/s00266-005-0089-x
M3 - Article
C2 - 16328631
AN - SCOPUS:29744455324
VL - 29
SP - 472
EP - 478
JO - Aesthetic Plastic Surgery
JF - Aesthetic Plastic Surgery
SN - 0364-216X
IS - 6
ER -