Chapter 14: Bioactive Glasses in Infection Treatment

Nina Lindfors, Carlo Romano, Sara Scarponi, Drago Lorenzo, Bortolin Monica, Janek Frantzén, Pieter D. De Veij Mestdagh, David R. Colnot, Pepijn A. Borggreven, Jasper J. Quak

Research output: Chapter in Book/Report/Conference proceedingChapter


Bone infection, whether acute or chronic, is a difficult-to-treat condition that may result from a large number of pathogens, often including multi-resistant strains. Bioactive glass S53P4 (BAG-S53P4) has been shown to inhibit bacterial growth and bacterial biofilm formation in vitro. The bacterial growth-inhibiting properties of BAG-S53P4 stem partly from the release of ions (sodium, calcium, phosphate, and silicate) in aqueous conditions and the elevation of pH and osmotic pressure in the environment. The use of BAG-S53P4 in head and neck surgery to treat chronically infected sinus and mastoid cavities has shown excellent results. More recently, investigations of the use of BAG-S53P4 in treating chronic bone infections in orthopaedics and trauma have also yielded promising results. To date, bioactive glass is the only medical device specifically approved for the treatment of bone defects in osteomyelitis without requiring the application of local antibiotics.

Original languageEnglish
Title of host publicationSelf-Cleaning Coatings
Subtitle of host publicationStructure, Fabrication and Application
PublisherRoyal Society of Chemistry
Number of pages20
Publication statusPublished - Jan 1 2017

Publication series

NameRSC Smart Materials
ISSN (Print)2046-0066
ISSN (Electronic)2046-0074

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Materials Science(all)
  • Energy Engineering and Power Technology
  • Electrical and Electronic Engineering


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