Natural Killer (NK) cells, a major actor of the innate immunity, play a central role in defences against viral infectious and tumor growth. NK cells are regulated by a number of surface receptors that either activate or inhibit their function. Of major interest are the inhibitory receptors specific for HLA-class I molecules. These receptors allow to discriminate between normal cells, expressing sufficient amounts of HLA-class I molecules, and cells that have lost the surface expression of one or more HLA-class I alleles, as it occurs in virus-infected or tumor cells. As shown by recent studies, NK cells can interact with dendritic cells (DC), another important player of the innate immunity. The cross-talk between these cells, taking place in inflamed tissues and lymph nodes, may shape the functional activities of both cell types and influence downstream adaptive responses initiated by the interaction between DC and T lymphocyte in secondary lymphoid tissues.
- Activating receptors
- Bacteria-induced dendritic cell maturation
- Dendritic cells
- HLA-class-I-specific inhibitory receptors
- Natural killer cells
ASJC Scopus subject areas
- Immunology and Allergy