Chapter 16. Membrane and soluble pattern recognition receptors: The unique functions of the long pentraxin PTX3

Alberto Mantovani, C. Garlanda, K. Otero, G. Peri, A. Vecchi, B. Bottazzi

Research output: Contribution to journalArticlepeer-review

Abstract

Pentraxin 3 (PTX3), the first long pentraxin identified, is characterized by a C-terminal pentraxin like domain, showing sequence similarity to C-reactive protein and serum amyloid P component, coupled with a N-terminal unrelated portion. PTX3 is made by diverse cell types, including endothelial cells, macrophages and dendritic cells, in response to proinflammatory signals such as interleukin 1, tumor necrosis factor and lipopolysaccharide. It binds different ligands, including Clq, apoptotic cells and microbial mojcties. PTX3 levels are

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalClinical and Experimental Allergy Reviews
Volume4
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Autoimmune disorders
  • Fertility
  • Inflammation
  • Innate immunity
  • Pattern recognition receptors
  • Pentraxins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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