Chapter 19. Chemokines and their receptors in asthma and chronic obstructive pulmonary disease

Francesco Sinigaglia, P. Panina Bordignon, D. D'Ambrosio

Research output: Contribution to journalArticle

Abstract

T-cell trafficking into pulmonary tissue is a critical component of the host defense response. Migration of T cells into the lung also appears to orchestrate inflammation, tissue injury and remodelling of tissue architecture. Accumulating evidence suggest that chemokines and their receptors constitute essential cues for the recruitment and localization of T cells into sites of inflammation. Because of the clinical importance of chemokines and the potential benefit of pharmaceutical intervention in the chemokine pathway, there have been many recent advances in the chemokine field. This review focuses on recent data either from clinical observations or animal models that have highlighted the role chemokine biology in asthma and COPD.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalClinical and Experimental Allergy Reviews
Volume4
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Asthma
  • Chemokines
  • COPD
  • Lymphocyte homing
  • T cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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