Chapter 21. First- and second-generation H1 antihistamines: From the molecular basis of their interaction with HERG K+ channels to physiological and pathophysiological implication

Maurizio Taglialatela, P. Castaldo, A. Pannaccione, A. Secondo, M. Cataldi, F. Boscia, L. Annunziato

Research output: Contribution to journalArticle


The present article reports on the recent findings addressing the molecular basis for some rare but serious cardiovascular side-effects exerted by some non-sedating H1-blocking antihistamines. These latest developments, which have allowed fundamental insights into the role played by a specific class of potassium channels, the so-called human ether-a-gogo-related gene (HERG) channels, in the regulation of cardiac action potential duration and rhythm regulation, have also opened new areas of investigation into its participation in neuronal and endocrine (adenohypophyseal, chromaffin, and pancreatic) cells functioning.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalClinical and Experimental Allergy Reviews
Issue numberSUPPL. 2
Publication statusPublished - Dec 2004



  • Antihistamines
  • Long QT syndrome
  • Potassium channels

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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