TY - JOUR
T1 - Chapter 21. First- and second-generation H1 antihistamines
T2 - From the molecular basis of their interaction with HERG K+ channels to physiological and pathophysiological implication
AU - Taglialatela, Maurizio
AU - Castaldo, P.
AU - Pannaccione, A.
AU - Secondo, A.
AU - Cataldi, M.
AU - Boscia, F.
AU - Annunziato, L.
PY - 2004/12
Y1 - 2004/12
N2 - The present article reports on the recent findings addressing the molecular basis for some rare but serious cardiovascular side-effects exerted by some non-sedating H1-blocking antihistamines. These latest developments, which have allowed fundamental insights into the role played by a specific class of potassium channels, the so-called human ether-a-gogo-related gene (HERG) channels, in the regulation of cardiac action potential duration and rhythm regulation, have also opened new areas of investigation into its participation in neuronal and endocrine (adenohypophyseal, chromaffin, and pancreatic) cells functioning.
AB - The present article reports on the recent findings addressing the molecular basis for some rare but serious cardiovascular side-effects exerted by some non-sedating H1-blocking antihistamines. These latest developments, which have allowed fundamental insights into the role played by a specific class of potassium channels, the so-called human ether-a-gogo-related gene (HERG) channels, in the regulation of cardiac action potential duration and rhythm regulation, have also opened new areas of investigation into its participation in neuronal and endocrine (adenohypophyseal, chromaffin, and pancreatic) cells functioning.
KW - Antihistamines
KW - Long QT syndrome
KW - Potassium channels
UR - http://www.scopus.com/inward/record.url?scp=11844277639&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11844277639&partnerID=8YFLogxK
U2 - 10.1111/j.1472-9725.2004.00053.x
DO - 10.1111/j.1472-9725.2004.00053.x
M3 - Article
AN - SCOPUS:11844277639
VL - 4
SP - 183
EP - 190
JO - Clinical and Experimental Allergy Reviews
JF - Clinical and Experimental Allergy Reviews
SN - 1472-9725
IS - SUPPL. 2
ER -