Chapter Ten More Than Two Sides of a Coin?. How to Detect the Multiple Activities of Type 2 Transglutaminase

Carlo Rodolfo, Laura Falasca, Giuseppina Di Giacomo, Pier Giorgio Mastroberardino, Mauro Piacentini

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Abstract

Programmed cell death (PCD) by apoptosis has been widely characterized as a process in which the expression and protein activation of a gene must be regulated in a very precise way in order to achieve the elimination of the dying cell without disturbing the neighborhoods. One of the first genes observed to be induced during the onset of PCD is the one coding for type 2 transglutaminase (TG2). Since the late 1990s, the unveiling of different new properties and enzymatic activities suggested the involvement of TG2 in a variety of cellular processes other than PCD and rendered the study of this protein more and more complicated.

Original languageEnglish
Pages (from-to)201-212
Number of pages12
JournalMethods in Enzymology
Volume442
DOIs
Publication statusPublished - 2008

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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