TY - JOUR
T1 - Characterisation of a β detector on positron emitters for medical applications
AU - Collamati, F
AU - Moretti, R
AU - Alunni-Solestizi, L
AU - Bocci, V
AU - Cartoni, A
AU - Collarino, A
AU - De Simoni, M
AU - Faccini, R
AU - Fischetti, M
AU - Giordano, A
AU - Maccora, D
AU - Mancini-Terracciano, C
AU - Mirabelli, R
AU - Scotognella, T
AU - Solfaroli-Camillocci, E
AU - Traini, G
AU - Morganti, S
N1 - Copyright © 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
PY - 2019/11
Y1 - 2019/11
N2 - PURPOSE: Radio Guided Surgery (RGS) is a technique that helps the surgeon to achieve an as complete as possible tumor resection, thanks to the intraoperative detection of particles emitted by a radio tracer that bounds to tumoral cells. In the last years, a novel approach to this technique has been proposed that, exploiting β- emitting radio tracers, overtakes some limitations of established γ-RGS. In this context, a first prototype of an intraoperative β particle detector, based on a high light yield and low density organic scintillator, has been developed and characterised on pure β- emitters, like 90Y. The demonstrated very high efficiency to β- particles, together with the remarkable transparency to photons, suggested the possibility to use this detector also with β+ emitting sources, that have plenty of applications in nuclear medicine. In this paper, we present upgrades and optimisations performed to the detector to reveal such particles.METHODS: Laboratory measurement have been performed on liquid Ga68 source, and were used to validate and tune a Monte Carlo simulation.RESULTS: The upgraded detector has an ~80% efficiency to electrons above ~110keV, reaching a plateau value of ~95%. At the same time, the probe is substantially transparent to photons below ~200keV, reaching a plateau value of ~3%.CONCLUSIONS: The new prototype seems to have promising characteristics to perform RGS also with β+ emitting isotopes.
AB - PURPOSE: Radio Guided Surgery (RGS) is a technique that helps the surgeon to achieve an as complete as possible tumor resection, thanks to the intraoperative detection of particles emitted by a radio tracer that bounds to tumoral cells. In the last years, a novel approach to this technique has been proposed that, exploiting β- emitting radio tracers, overtakes some limitations of established γ-RGS. In this context, a first prototype of an intraoperative β particle detector, based on a high light yield and low density organic scintillator, has been developed and characterised on pure β- emitters, like 90Y. The demonstrated very high efficiency to β- particles, together with the remarkable transparency to photons, suggested the possibility to use this detector also with β+ emitting sources, that have plenty of applications in nuclear medicine. In this paper, we present upgrades and optimisations performed to the detector to reveal such particles.METHODS: Laboratory measurement have been performed on liquid Ga68 source, and were used to validate and tune a Monte Carlo simulation.RESULTS: The upgraded detector has an ~80% efficiency to electrons above ~110keV, reaching a plateau value of ~95%. At the same time, the probe is substantially transparent to photons below ~200keV, reaching a plateau value of ~3%.CONCLUSIONS: The new prototype seems to have promising characteristics to perform RGS also with β+ emitting isotopes.
U2 - 10.1016/j.ejmp.2019.10.025
DO - 10.1016/j.ejmp.2019.10.025
M3 - Article
C2 - 31704391
VL - 67
SP - 85
EP - 90
JO - Physica Medica
JF - Physica Medica
SN - 1120-1797
ER -