Characterisation of a β detector on positron emitters for medical applications

F Collamati; R Moretti; L Alunni-Solestizi; V Bocci; A Cartoni; A Collarino; M De Simoni; R Faccini; M Fischetti; A Giordano; D Maccora; C Mancini-Terracciano; R Mirabelli; T Scotognella; E Solfaroli-Camillocci; G Traini; S Morganti

doi:10.1016/j.ejmp.2019.10.025

Characterisation of a β detector on positron emitters for medical applications

F Collamati, R Moretti, L Alunni-Solestizi, V Bocci, A Cartoni, A Collarino, M De Simoni, R Faccini, M Fischetti, A Giordano, D Maccora, C Mancini-Terracciano, R Mirabelli, T Scotognella, E Solfaroli-Camillocci, G Traini, S Morganti

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: Radio Guided Surgery (RGS) is a technique that helps the surgeon to achieve an as complete as possible tumor resection, thanks to the intraoperative detection of particles emitted by a radio tracer that bounds to tumoral cells. In the last years, a novel approach to this technique has been proposed that, exploiting β- emitting radio tracers, overtakes some limitations of established γ-RGS. In this context, a first prototype of an intraoperative β particle detector, based on a high light yield and low density organic scintillator, has been developed and characterised on pure β- emitters, like 90Y. The demonstrated very high efficiency to β- particles, together with the remarkable transparency to photons, suggested the possibility to use this detector also with β+ emitting sources, that have plenty of applications in nuclear medicine. In this paper, we present upgrades and optimisations performed to the detector to reveal such particles.

METHODS: Laboratory measurement have been performed on liquid Ga68 source, and were used to validate and tune a Monte Carlo simulation.

RESULTS: The upgraded detector has an ~80% efficiency to electrons above ~110keV, reaching a plateau value of ~95%. At the same time, the probe is substantially transparent to photons below ~200keV, reaching a plateau value of ~3%.

CONCLUSIONS: The new prototype seems to have promising characteristics to perform RGS also with β+ emitting isotopes.

Original language	English
Pages (from-to)	85-90
Number of pages	6
Journal	Physica Medica
Volume	67
DOIs	https://doi.org/10.1016/j.ejmp.2019.10.025
Publication status	Published - Nov 2019

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Collamati, F., Moretti, R., Alunni-Solestizi, L., Bocci, V., Cartoni, A., Collarino, A., De Simoni, M., Faccini, R., Fischetti, M., Giordano, A., Maccora, D., Mancini-Terracciano, C., Mirabelli, R., Scotognella, T., Solfaroli-Camillocci, E., Traini, G., & Morganti, S. (2019). Characterisation of a β detector on positron emitters for medical applications. Physica Medica, 67, 85-90. https://doi.org/10.1016/j.ejmp.2019.10.025

Characterisation of a β detector on positron emitters for medical applications. / Collamati, F; Moretti, R; Alunni-Solestizi, L; Bocci, V; Cartoni, A; Collarino, A; De Simoni, M; Faccini, R; Fischetti, M; Giordano, A; Maccora, D; Mancini-Terracciano, C; Mirabelli, R; Scotognella, T; Solfaroli-Camillocci, E; Traini, G; Morganti, S.

In: Physica Medica, Vol. 67, 11.2019, p. 85-90.

Research output: Contribution to journal › Article › peer-review

Collamati, F, Moretti, R, Alunni-Solestizi, L, Bocci, V, Cartoni, A, Collarino, A, De Simoni, M, Faccini, R, Fischetti, M, Giordano, A, Maccora, D, Mancini-Terracciano, C, Mirabelli, R, Scotognella, T, Solfaroli-Camillocci, E, Traini, G & Morganti, S 2019, 'Characterisation of a β detector on positron emitters for medical applications', Physica Medica, vol. 67, pp. 85-90. https://doi.org/10.1016/j.ejmp.2019.10.025

Collamati, F ; Moretti, R ; Alunni-Solestizi, L ; Bocci, V ; Cartoni, A ; Collarino, A ; De Simoni, M ; Faccini, R ; Fischetti, M ; Giordano, A ; Maccora, D ; Mancini-Terracciano, C ; Mirabelli, R ; Scotognella, T ; Solfaroli-Camillocci, E ; Traini, G ; Morganti, S. / Characterisation of a β detector on positron emitters for medical applications. In: Physica Medica. 2019 ; Vol. 67. pp. 85-90.

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title = "Characterisation of a β detector on positron emitters for medical applications",

abstract = "PURPOSE: Radio Guided Surgery (RGS) is a technique that helps the surgeon to achieve an as complete as possible tumor resection, thanks to the intraoperative detection of particles emitted by a radio tracer that bounds to tumoral cells. In the last years, a novel approach to this technique has been proposed that, exploiting β- emitting radio tracers, overtakes some limitations of established γ-RGS. In this context, a first prototype of an intraoperative β particle detector, based on a high light yield and low density organic scintillator, has been developed and characterised on pure β- emitters, like 90Y. The demonstrated very high efficiency to β- particles, together with the remarkable transparency to photons, suggested the possibility to use this detector also with β+ emitting sources, that have plenty of applications in nuclear medicine. In this paper, we present upgrades and optimisations performed to the detector to reveal such particles.METHODS: Laboratory measurement have been performed on liquid Ga68 source, and were used to validate and tune a Monte Carlo simulation.RESULTS: The upgraded detector has an ~80% efficiency to electrons above ~110keV, reaching a plateau value of ~95%. At the same time, the probe is substantially transparent to photons below ~200keV, reaching a plateau value of ~3%.CONCLUSIONS: The new prototype seems to have promising characteristics to perform RGS also with β+ emitting isotopes.",

author = "F Collamati and R Moretti and L Alunni-Solestizi and V Bocci and A Cartoni and A Collarino and {De Simoni}, M and R Faccini and M Fischetti and A Giordano and D Maccora and C Mancini-Terracciano and R Mirabelli and T Scotognella and E Solfaroli-Camillocci and G Traini and S Morganti",

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AU - Collamati, F

AU - Moretti, R

AU - Alunni-Solestizi, L

AU - Bocci, V

AU - Cartoni, A

AU - Collarino, A

AU - De Simoni, M

AU - Faccini, R

AU - Fischetti, M

AU - Giordano, A

AU - Maccora, D

AU - Mancini-Terracciano, C

AU - Mirabelli, R

AU - Scotognella, T

AU - Solfaroli-Camillocci, E

AU - Traini, G

AU - Morganti, S

PY - 2019/11

Y1 - 2019/11

N2 - PURPOSE: Radio Guided Surgery (RGS) is a technique that helps the surgeon to achieve an as complete as possible tumor resection, thanks to the intraoperative detection of particles emitted by a radio tracer that bounds to tumoral cells. In the last years, a novel approach to this technique has been proposed that, exploiting β- emitting radio tracers, overtakes some limitations of established γ-RGS. In this context, a first prototype of an intraoperative β particle detector, based on a high light yield and low density organic scintillator, has been developed and characterised on pure β- emitters, like 90Y. The demonstrated very high efficiency to β- particles, together with the remarkable transparency to photons, suggested the possibility to use this detector also with β+ emitting sources, that have plenty of applications in nuclear medicine. In this paper, we present upgrades and optimisations performed to the detector to reveal such particles.METHODS: Laboratory measurement have been performed on liquid Ga68 source, and were used to validate and tune a Monte Carlo simulation.RESULTS: The upgraded detector has an ~80% efficiency to electrons above ~110keV, reaching a plateau value of ~95%. At the same time, the probe is substantially transparent to photons below ~200keV, reaching a plateau value of ~3%.CONCLUSIONS: The new prototype seems to have promising characteristics to perform RGS also with β+ emitting isotopes.

AB - PURPOSE: Radio Guided Surgery (RGS) is a technique that helps the surgeon to achieve an as complete as possible tumor resection, thanks to the intraoperative detection of particles emitted by a radio tracer that bounds to tumoral cells. In the last years, a novel approach to this technique has been proposed that, exploiting β- emitting radio tracers, overtakes some limitations of established γ-RGS. In this context, a first prototype of an intraoperative β particle detector, based on a high light yield and low density organic scintillator, has been developed and characterised on pure β- emitters, like 90Y. The demonstrated very high efficiency to β- particles, together with the remarkable transparency to photons, suggested the possibility to use this detector also with β+ emitting sources, that have plenty of applications in nuclear medicine. In this paper, we present upgrades and optimisations performed to the detector to reveal such particles.METHODS: Laboratory measurement have been performed on liquid Ga68 source, and were used to validate and tune a Monte Carlo simulation.RESULTS: The upgraded detector has an ~80% efficiency to electrons above ~110keV, reaching a plateau value of ~95%. At the same time, the probe is substantially transparent to photons below ~200keV, reaching a plateau value of ~3%.CONCLUSIONS: The new prototype seems to have promising characteristics to perform RGS also with β+ emitting isotopes.

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