Characterisation of a β detector on positron emitters for medical applications

F Collamati, R Moretti, L Alunni-Solestizi, V Bocci, A Cartoni, A Collarino, M De Simoni, R Faccini, M Fischetti, A Giordano, D Maccora, C Mancini-Terracciano, R Mirabelli, T Scotognella, E Solfaroli-Camillocci, G Traini, S Morganti

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: Radio Guided Surgery (RGS) is a technique that helps the surgeon to achieve an as complete as possible tumor resection, thanks to the intraoperative detection of particles emitted by a radio tracer that bounds to tumoral cells. In the last years, a novel approach to this technique has been proposed that, exploiting β- emitting radio tracers, overtakes some limitations of established γ-RGS. In this context, a first prototype of an intraoperative β particle detector, based on a high light yield and low density organic scintillator, has been developed and characterised on pure β- emitters, like 90Y. The demonstrated very high efficiency to β- particles, together with the remarkable transparency to photons, suggested the possibility to use this detector also with β+ emitting sources, that have plenty of applications in nuclear medicine. In this paper, we present upgrades and optimisations performed to the detector to reveal such particles.

METHODS: Laboratory measurement have been performed on liquid Ga68 source, and were used to validate and tune a Monte Carlo simulation.

RESULTS: The upgraded detector has an ~80% efficiency to electrons above ~110keV, reaching a plateau value of ~95%. At the same time, the probe is substantially transparent to photons below ~200keV, reaching a plateau value of ~3%.

CONCLUSIONS: The new prototype seems to have promising characteristics to perform RGS also with β+ emitting isotopes.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalPhysica Medica
Volume67
DOIs
Publication statusPublished - Nov 2019

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