Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517)

L. Capolongo, G. Melegaro, M. Broggini, N. Mongelli, M. Grandi

Research output: Contribution to journalArticle

Abstract

Human colon adenocarcinoma cells (LoVo) resistant to the new antitumor agent FCE 24517 [benzoyl-mustard derivative of distamycin A] (LoVo/24517) are resistant to the selecting agent and related molecules as well as to vinblastine, with marginal or no resistance to other antitumour drugs. Treatment with verapamil, tamoxifen, nicergoline or cyclosporin A only partially restores the activity of FCE 24517 against LoVo/24517 cells. Such results suggest that resistance mechanisms possible specific for this class of compounds are operating.

Original languageEnglish
Pages (from-to)916-919
Number of pages4
JournalBritish Journal of Cancer
Volume68
Issue number5
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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