Characteristic of chronic plaque psoriasis patients treated with biologics in Italy during the COVID-19 Pandemic: Risk analysis from the PSO-BIO-COVID observational study

PSO-BIO-COVID study group, M. Talamonti, M. Galluzzo, A. Chiricozzi, P. Quaglino, G. Fabbrocini, P. Gisondi, A.V. Marzano, C. Potenza, A. Conti, A. Parodi, S. Piaserico, F. Bardazzi, G. Argenziano, F. Rongioletti, L. Stingeni, G. Micali, F. Loconsole, M.T. Rossi, M.R. BongiornoC. Feliciani, P. Rubegni, P. Amerio, M.C. Fargnoli, P. Pigatto, P. Savoia, S.P. Nisticò, S. Giustini, A. Carugno, S.P. Cannavo’, G. Rech, F. Prignano, A. Offidani, M. Lombardo, I. Zalaudek, L. Bianchi, K. Peris

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The susceptibility of patients with chronic plaque psoriasis and the risks or benefits related to the use of biological therapies for COVID-19 are unknown. Few data about prevalence, clinical course and outcomes of COVID-19 among psoriatic patients were reported. The aims of this study were 1) to assess the prevalence and severity of COVID-19 in psoriatic patients treated with biologic agents during the first phase of the emergency (22 February to 22 April 2020) in Italy, and 2) to report the clinical outcomes of patients who have been exposed to individuals with confirmed SARS-CoV-2 infection. Methods: Patients with moderate-to-severe chronic plaque psoriasis, aged ≥18 years and undergoing treatment with biologic agents as of 22 February 2020, were eligible to be included in PSO-BIO-COVID study. Demographic and clinical characteristics of patients using any biologic for psoriasis treatment between 22 February and 22 April 2020 were registered. Results: A total of 12,807 psoriatic patients were included in the PSO-BIO-COVID study. In this cohort 26 patients (0.2%) had a swab confirmation of SARS-CoV-2 infection. Eleven patients required hospitalization and two died. Conclusion: The incidence of COVID-19 observed in our cohort of psoriatic patients (0.2%) is similar to that seen in the general population (0.31%) in Italy. However, the course of the disease was mild in most patients. Biological therapies may likely lessen ‘cytokine storm’ of COVID-19, which sometimes lead to multiple organ failure, ARDS, and death.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalExpert Opinion on Biological Therapy
Volume21
Issue number2
DOIs
Publication statusPublished - 2021

Keywords

  • biological therapy
  • COVID-19
  • dermatology
  • psoriasis
  • sars-CoV-2
  • biological product
  • IL23R protein, human
  • interleukin 17
  • interleukin receptor
  • tumor necrosis factor
  • adult
  • aged
  • chronic disease
  • clinical trial
  • cohort analysis
  • female
  • human
  • incidence
  • Italy
  • male
  • middle aged
  • multicenter study
  • pandemic
  • procedures
  • risk assessment
  • very elderly
  • young adult
  • Adult
  • Aged
  • Aged, 80 and over
  • Biological Products
  • Biological Therapy
  • Chronic Disease
  • Cohort Studies
  • Female
  • Humans
  • Incidence
  • Interleukin-17
  • Male
  • Middle Aged
  • Pandemics
  • Psoriasis
  • Receptors, Interleukin
  • Risk Assessment
  • Tumor Necrosis Factor-alpha
  • Young Adult

Fingerprint

Dive into the research topics of 'Characteristic of chronic plaque psoriasis patients treated with biologics in Italy during the COVID-19 Pandemic: Risk analysis from the PSO-BIO-COVID observational study'. Together they form a unique fingerprint.

Cite this