Characteristic ultrastructural changes in the glomerular basement membrane and localisation of osmiophilic deposits

H. U. Zollinger; M. J. Mihatsch; F. Gaboardi; G. Banfi; A. Edefonti; M. Bardare; F. Gudat

doi:10.1007/BF00430684

Characteristic ultrastructural changes in the glomerular basement membrane and localisation of osmiophilic deposits

H. U. Zollinger, M. J. Mihatsch, F. Gaboardi, G. Banfi, A. Edefonti, M. Bardare, F. Gudat

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

In glomerulonephritis accompanying the Schönlein-Henoch syndrome (SHS) a characteristic subepithelial basement membrane change is present in 85% of cases. The subepithelial change is a reaction to subepithelial deposits and consists of a garland or dome-like new formation of thin densa lamellae. This change is much more frequent in SHS than in IgA-nephritis or idiopathic glomerulonephritis or any other systemic disease. Furthermore, subepithelial deposits (50% of cases) are nearly as frequent as subendothelial deposits (65%) and more often present than formerly assumed.

Original language	English
Pages (from-to)	155-165
Number of pages	11
Journal	Virchows Archiv A Pathological Anatomy and Histology
Volume	388
Issue number	2
DOIs	https://doi.org/10.1007/BF00430684
Publication status	Published - Sep 1980

Keywords

Glomerular basement membrane
Glomerulonephritis
Schönlein-Henoch's disease

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Anatomy
Medicine(all)

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10.1007/BF00430684

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title = "Characteristic ultrastructural changes in the glomerular basement membrane and localisation of osmiophilic deposits",

abstract = "In glomerulonephritis accompanying the Sch{\"o}nlein-Henoch syndrome (SHS) a characteristic subepithelial basement membrane change is present in 85% of cases. The subepithelial change is a reaction to subepithelial deposits and consists of a garland or dome-like new formation of thin densa lamellae. This change is much more frequent in SHS than in IgA-nephritis or idiopathic glomerulonephritis or any other systemic disease. Furthermore, subepithelial deposits (50% of cases) are nearly as frequent as subendothelial deposits (65%) and more often present than formerly assumed.",

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T1 - Characteristic ultrastructural changes in the glomerular basement membrane and localisation of osmiophilic deposits

AU - Zollinger, H. U.

AU - Mihatsch, M. J.

AU - Gaboardi, F.

AU - Banfi, G.

AU - Edefonti, A.

AU - Bardare, M.

AU - Gudat, F.

PY - 1980/9

Y1 - 1980/9

N2 - In glomerulonephritis accompanying the Schönlein-Henoch syndrome (SHS) a characteristic subepithelial basement membrane change is present in 85% of cases. The subepithelial change is a reaction to subepithelial deposits and consists of a garland or dome-like new formation of thin densa lamellae. This change is much more frequent in SHS than in IgA-nephritis or idiopathic glomerulonephritis or any other systemic disease. Furthermore, subepithelial deposits (50% of cases) are nearly as frequent as subendothelial deposits (65%) and more often present than formerly assumed.

AB - In glomerulonephritis accompanying the Schönlein-Henoch syndrome (SHS) a characteristic subepithelial basement membrane change is present in 85% of cases. The subepithelial change is a reaction to subepithelial deposits and consists of a garland or dome-like new formation of thin densa lamellae. This change is much more frequent in SHS than in IgA-nephritis or idiopathic glomerulonephritis or any other systemic disease. Furthermore, subepithelial deposits (50% of cases) are nearly as frequent as subendothelial deposits (65%) and more often present than formerly assumed.

KW - Glomerular basement membrane

KW - Glomerulonephritis

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Characteristic ultrastructural changes in the glomerular basement membrane and localisation of osmiophilic deposits

Abstract

Keywords

ASJC Scopus subject areas

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