Characteristic ultrastructural changes in the glomerular basement membrane and localisation of osmiophilic deposits

H. U. Zollinger, M. J. Mihatsch, F. Gaboardi, G. Banfi, A. Edefonti, M. Bardare, F. Gudat

Research output: Contribution to journalArticlepeer-review

Abstract

In glomerulonephritis accompanying the Schönlein-Henoch syndrome (SHS) a characteristic subepithelial basement membrane change is present in 85% of cases. The subepithelial change is a reaction to subepithelial deposits and consists of a garland or dome-like new formation of thin densa lamellae. This change is much more frequent in SHS than in IgA-nephritis or idiopathic glomerulonephritis or any other systemic disease. Furthermore, subepithelial deposits (50% of cases) are nearly as frequent as subendothelial deposits (65%) and more often present than formerly assumed.

Original languageEnglish
Pages (from-to)155-165
Number of pages11
JournalVirchows Archiv A Pathological Anatomy and Histology
Volume388
Issue number2
DOIs
Publication statusPublished - Sep 1980

Keywords

  • Glomerular basement membrane
  • Glomerulonephritis
  • Schönlein-Henoch's disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Anatomy
  • Medicine(all)

Fingerprint Dive into the research topics of 'Characteristic ultrastructural changes in the glomerular basement membrane and localisation of osmiophilic deposits'. Together they form a unique fingerprint.

Cite this