Characteristics and biological role of steroid hormone receptors in neuroepithelial tumors

P. Paoletti, G. Butti, C. Zibera, M. Scerrati, N. Gibelli, R. Roselli, L. Magrassi, G. Sica, G. Rossi, G. Robustelli Della Cuna

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Tissue samples from 57 patients with neuroepithelial tumors (25 glioblastomas, 18 anaplastic astrocytomas, and 14 astrocytomas) were analyzed in order to evaluate the presence of estrogen, progesterone, glucocorticoid, and androgen receptors. Glucocorticoid- and androgen-specific binding proteins were present in 38.6% and 21.6% of the cases, respectively. Only a few tumors showed estrogen or progesterone receptors. A correlation was found between grade of anaplasia, patient's sex and age, and presence of glucocorticoid and androgen receptors. The biological role of these two receptors was investigated in 10 primary cell cultures derived from neuroepithelial tumors. For this purpose, dexamethasone and testosterone were added to culture medium at different concentrations (from 50 to 0.016 μg/ml). A significant stimulation of the cell growth was observed in four of five glucocorticoid receptor-positive cultures when dexamethasone in doses ranging from 2 to 0.016 μg/ml was added to the culture. No modulation of the growth was observed in glucocorticoid receptor-negative cultures at the same doses. Higher dexamethasone doses induced a significant decrease of the growth index independently from the glucocorticoid receptor status. All of the cultures tested for testosterone activity were negative for androgen receptors. This hormone induced an inhibition of the growth index at doses ranging from 50 to 0.4 μg/ml. The data suggest that neuroepithelial tumors contain specific glucocorticoid and androgen binding proteins. Glucocorticoid receptors modulate the growth of cultured neuroepithelial tumors in the presence of different concentrations of dexamethasone.

Original languageEnglish
Pages (from-to)736-742
Number of pages7
JournalJournal of Neurosurgery
Volume73
Issue number5
Publication statusPublished - 1990

Fingerprint

Neuroepithelial Neoplasms
Steroid Receptors
Glucocorticoid Receptors
Hormones
Dexamethasone
Androgen Receptors
Androgen-Binding Protein
Growth
Astrocytoma
Progesterone Receptors
Estrogen Receptors
Glucocorticoids
Testosterone
Anaplasia
Primary Cell Culture
Glioblastoma
Culture Media

Keywords

  • dexamethasone
  • estrogen receptor
  • glioblastoma
  • neuroepithelial tumor
  • progesterone receptor
  • steroid hormone receptors

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Paoletti, P., Butti, G., Zibera, C., Scerrati, M., Gibelli, N., Roselli, R., ... Robustelli Della Cuna, G. (1990). Characteristics and biological role of steroid hormone receptors in neuroepithelial tumors. Journal of Neurosurgery, 73(5), 736-742.

Characteristics and biological role of steroid hormone receptors in neuroepithelial tumors. / Paoletti, P.; Butti, G.; Zibera, C.; Scerrati, M.; Gibelli, N.; Roselli, R.; Magrassi, L.; Sica, G.; Rossi, G.; Robustelli Della Cuna, G.

In: Journal of Neurosurgery, Vol. 73, No. 5, 1990, p. 736-742.

Research output: Contribution to journalArticle

Paoletti, P, Butti, G, Zibera, C, Scerrati, M, Gibelli, N, Roselli, R, Magrassi, L, Sica, G, Rossi, G & Robustelli Della Cuna, G 1990, 'Characteristics and biological role of steroid hormone receptors in neuroepithelial tumors', Journal of Neurosurgery, vol. 73, no. 5, pp. 736-742.
Paoletti P, Butti G, Zibera C, Scerrati M, Gibelli N, Roselli R et al. Characteristics and biological role of steroid hormone receptors in neuroepithelial tumors. Journal of Neurosurgery. 1990;73(5):736-742.
Paoletti, P. ; Butti, G. ; Zibera, C. ; Scerrati, M. ; Gibelli, N. ; Roselli, R. ; Magrassi, L. ; Sica, G. ; Rossi, G. ; Robustelli Della Cuna, G. / Characteristics and biological role of steroid hormone receptors in neuroepithelial tumors. In: Journal of Neurosurgery. 1990 ; Vol. 73, No. 5. pp. 736-742.
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