Characteristics and outcomes of MitraClip in octogenarians: Evidence from 1853 patients in the GIOTTO registry

Arturo Giordano, Giuseppe Biondi-Zoccai, Filippo Finizio, Paolo Ferraro, Paolo Denti, Antonio Popolo Rubbio, Anna Sonia Petronio, Antonio L. Bartorelli, Annalisa Mongiardo, Francesco De Felice, Marianna Adamo, Matteo Montorfano, Cesare Baldi, Giuseppe Tarantini, Francesco Giannini, Federico Ronco, Ida Monteforte, Emmanuel Villa, Maurizio Ferrario, Luigi FioccaFausto Castriota, Corrado Tamburino

Research output: Contribution to journalArticlepeer-review


Background: We aimed at appraising features and outcomes of patients undergoing MitraClip treatment according to their age. Methods: We queried the prospective GIse registry Of Transcatheter treatment of mitral valve regurgitaTiOn (GIOTTO) multicenter registry dataset including 19 Italian centers performing MitraClip implantation, distinguishing patients <80 vs ≥80 years of age. Results: In total, 1853 patients were included, 751 (40.5%) octogenarians and 1102 (59.5%) non-octogenarians. Several baseline and procedural features were significantly different, including gender, regurgitation etiology, and functional class (all p < 0.05). In-hospital outcomes were similarly satisfactory, with death occurring in 18 (2.4%) and 32 (2.9%, p = 0.561), respectively, and improvement in mitral regurgitation in 732 (97.4%) and 1078 (97.8%, p = 0.746), respectively. After a mean follow-up of 15 months, death occurred in 152 (20.2%) and 264 (24.0%), and cardiac death in 85 (11.3%) and 138 (12.5%), respectively (both p > 0.05). Rehospitalization for heart failure and the composite of cardiac death or rehospitalization for heart failure were significantly less common in octogenarians: 63 (8.4%) vs 156 (14.2%, p < 0.001), and 125 (16.6%) vs 242 (22.0%, p = 0.005), respectively. Multivariable analysis showed that these differences were largely due to confounding features, as after adjustment for baseline, clinical and imaging characteristics no significant difference was found for the above clinical endpoints. Conclusions: Transcatheter mitral valve repair with the MitraClip in carefully selected octogenarians appears feasible and safe, and is associated with favorable clinical outcomes at mid-term follow-up.

Original languageEnglish
JournalInternational Journal of Cardiology
Publication statusAccepted/In press - 2021


  • Elderly
  • MitraClip
  • Mitral regurgitation
  • Octogenarian

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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