Abstract
Purpose: To describe the characteristics at presentation and the outcome of elderly patients (≥70 years old) with HCC, a retrospective analysis using a CLIP database was performed. Patients and methods: The database included 650 patients. χ2-test, logistic and Cox model were applied. Results: Baseline characteristics and stage were similarly among elderly (n = 158) and non-elderly (n = 492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p <0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival. Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.
| Original language | English |
|---|---|
| Pages (from-to) | 243-249 |
| Number of pages | 7 |
| Journal | Critical Reviews in Oncology/Hematology |
| Volume | 59 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2006 |
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Keywords
- CLIP score
- Elderly
- Hepatocellular carcinoma
- Prognosis
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP). / Pignata, Sandro; Gallo, Ciro; Daniele, Bruno; Elba, Silvana; Giorgio, Antonio; Capuano, Gaetano; Adinolfi, Luigi Elio; De Sio, Ilario; Izzo, Francesco; Farinati, Fabio; Naja, Carlo Del; Stanzione, Maria; Castiglione, Fabiana; Marone, Giampiero; Cuomo, Oreste; Felder, Martina; Gaeta, Giovanni Battista; Maio, Ermelinda De; Maio, Massimo Di; Signoriello, Giuseppe; Perrone, Francesco.
In: Critical Reviews in Oncology/Hematology, Vol. 59, No. 3, 09.2006, p. 243-249.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)
AU - Pignata, Sandro
AU - Gallo, Ciro
AU - Daniele, Bruno
AU - Elba, Silvana
AU - Giorgio, Antonio
AU - Capuano, Gaetano
AU - Adinolfi, Luigi Elio
AU - De Sio, Ilario
AU - Izzo, Francesco
AU - Farinati, Fabio
AU - Naja, Carlo Del
AU - Stanzione, Maria
AU - Castiglione, Fabiana
AU - Marone, Giampiero
AU - Cuomo, Oreste
AU - Felder, Martina
AU - Gaeta, Giovanni Battista
AU - Maio, Ermelinda De
AU - Maio, Massimo Di
AU - Signoriello, Giuseppe
AU - Perrone, Francesco
PY - 2006/9
Y1 - 2006/9
N2 - Purpose: To describe the characteristics at presentation and the outcome of elderly patients (≥70 years old) with HCC, a retrospective analysis using a CLIP database was performed. Patients and methods: The database included 650 patients. χ2-test, logistic and Cox model were applied. Results: Baseline characteristics and stage were similarly among elderly (n = 158) and non-elderly (n = 492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p <0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival. Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.
AB - Purpose: To describe the characteristics at presentation and the outcome of elderly patients (≥70 years old) with HCC, a retrospective analysis using a CLIP database was performed. Patients and methods: The database included 650 patients. χ2-test, logistic and Cox model were applied. Results: Baseline characteristics and stage were similarly among elderly (n = 158) and non-elderly (n = 492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p <0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival. Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.
KW - CLIP score
KW - Elderly
KW - Hepatocellular carcinoma
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=33748035393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748035393&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2006.01.002
DO - 10.1016/j.critrevonc.2006.01.002
M3 - Article
VL - 59
SP - 243
EP - 249
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
SN - 1040-8428
IS - 3
ER -