Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)

Sandro Pignata, Ciro Gallo, Bruno Daniele, Silvana Elba, Antonio Giorgio, Gaetano Capuano, Luigi Elio Adinolfi, Ilario De Sio, Francesco Izzo, Fabio Farinati, Carlo Del Naja, Maria Stanzione, Fabiana Castiglione, Giampiero Marone, Oreste Cuomo, Martina Felder, Giovanni Battista Gaeta, Ermelinda De Maio, Massimo Di Maio, Giuseppe SignorielloFrancesco Perrone

Research output: Contribution to journalArticle

Abstract

Purpose: To describe the characteristics at presentation and the outcome of elderly patients (≥70 years old) with HCC, a retrospective analysis using a CLIP database was performed. Patients and methods: The database included 650 patients. χ2-test, logistic and Cox model were applied. Results: Baseline characteristics and stage were similarly among elderly (n = 158) and non-elderly (n = 492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p <0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival. Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalCritical Reviews in Oncology/Hematology
Volume59
Issue number3
DOIs
Publication statusPublished - Sep 2006

Keywords

  • CLIP score
  • Elderly
  • Hepatocellular carcinoma
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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