Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)

Sandro Pignata; Ciro Gallo; Bruno Daniele; Silvana Elba; Antonio Giorgio; Gaetano Capuano; Luigi Elio Adinolfi; Ilario De Sio; Francesco Izzo; Fabio Farinati; Carlo Del Naja; Maria Stanzione; Fabiana Castiglione; Giampiero Marone; Oreste Cuomo; Martina Felder; Giovanni Battista Gaeta; Ermelinda De Maio; Massimo Di Maio; Giuseppe Signoriello; Francesco Perrone

doi:10.1016/j.critrevonc.2006.01.002

Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)

Sandro Pignata, Ciro Gallo, Bruno Daniele, Silvana Elba, Antonio Giorgio, Gaetano Capuano, Luigi Elio Adinolfi, Ilario De Sio, Francesco Izzo, Fabio Farinati, Carlo Del Naja, Maria Stanzione, Fabiana Castiglione, Giampiero Marone, Oreste Cuomo, Martina Felder, Giovanni Battista Gaeta, Ermelinda De Maio, Massimo Di Maio, Giuseppe SignorielloFrancesco Perrone

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article

Abstract

Purpose: To describe the characteristics at presentation and the outcome of elderly patients (≥70 years old) with HCC, a retrospective analysis using a CLIP database was performed. Patients and methods: The database included 650 patients. χ2-test, logistic and Cox model were applied. Results: Baseline characteristics and stage were similarly among elderly (n = 158) and non-elderly (n = 492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p <0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival. Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.

Original language	English
Pages (from-to)	243-249
Number of pages	7
Journal	Critical Reviews in Oncology/Hematology
Volume	59
Issue number	3
DOIs	https://doi.org/10.1016/j.critrevonc.2006.01.002
Publication status	Published - Sep 2006

Keywords

CLIP score
Elderly
Hepatocellular carcinoma
Prognosis

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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Pignata, S., Gallo, C., Daniele, B., Elba, S., Giorgio, A., Capuano, G., Adinolfi, L. E., De Sio, I., Izzo, F., Farinati, F., Naja, C. D., Stanzione, M., Castiglione, F., Marone, G., Cuomo, O., Felder, M., Gaeta, G. B., Maio, E. D., Maio, M. D., ... Perrone, F. (2006). Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP). Critical Reviews in Oncology/Hematology, 59(3), 243-249. https://doi.org/10.1016/j.critrevonc.2006.01.002

Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP). / Pignata, Sandro; Gallo, Ciro; Daniele, Bruno; Elba, Silvana; Giorgio, Antonio; Capuano, Gaetano; Adinolfi, Luigi Elio; De Sio, Ilario; Izzo, Francesco; Farinati, Fabio; Naja, Carlo Del; Stanzione, Maria; Castiglione, Fabiana; Marone, Giampiero; Cuomo, Oreste; Felder, Martina; Gaeta, Giovanni Battista; Maio, Ermelinda De; Maio, Massimo Di; Signoriello, Giuseppe; Perrone, Francesco.

In: Critical Reviews in Oncology/Hematology, Vol. 59, No. 3, 09.2006, p. 243-249.

Research output: Contribution to journal › Article

Pignata, S, Gallo, C, Daniele, B, Elba, S, Giorgio, A, Capuano, G, Adinolfi, LE, De Sio, I, Izzo, F, Farinati, F, Naja, CD, Stanzione, M, Castiglione, F, Marone, G, Cuomo, O, Felder, M, Gaeta, GB, Maio, ED, Maio, MD, Signoriello, G & Perrone, F 2006, 'Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)', Critical Reviews in Oncology/Hematology, vol. 59, no. 3, pp. 243-249. https://doi.org/10.1016/j.critrevonc.2006.01.002

Pignata, Sandro ; Gallo, Ciro ; Daniele, Bruno ; Elba, Silvana ; Giorgio, Antonio ; Capuano, Gaetano ; Adinolfi, Luigi Elio ; De Sio, Ilario ; Izzo, Francesco ; Farinati, Fabio ; Naja, Carlo Del ; Stanzione, Maria ; Castiglione, Fabiana ; Marone, Giampiero ; Cuomo, Oreste ; Felder, Martina ; Gaeta, Giovanni Battista ; Maio, Ermelinda De ; Maio, Massimo Di ; Signoriello, Giuseppe ; Perrone, Francesco. / Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP). In: Critical Reviews in Oncology/Hematology. 2006 ; Vol. 59, No. 3. pp. 243-249.

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abstract = "Purpose: To describe the characteristics at presentation and the outcome of elderly patients (≥70 years old) with HCC, a retrospective analysis using a CLIP database was performed. Patients and methods: The database included 650 patients. χ2-test, logistic and Cox model were applied. Results: Baseline characteristics and stage were similarly among elderly (n = 158) and non-elderly (n = 492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p <0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival. Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.",

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AU - Gallo, Ciro

AU - Daniele, Bruno

AU - Elba, Silvana

AU - Giorgio, Antonio

AU - Capuano, Gaetano

AU - Adinolfi, Luigi Elio

AU - De Sio, Ilario

AU - Izzo, Francesco

AU - Farinati, Fabio

AU - Naja, Carlo Del

AU - Stanzione, Maria

AU - Castiglione, Fabiana

AU - Marone, Giampiero

AU - Cuomo, Oreste

AU - Felder, Martina

AU - Gaeta, Giovanni Battista

AU - Maio, Ermelinda De

AU - Maio, Massimo Di

AU - Signoriello, Giuseppe

AU - Perrone, Francesco

PY - 2006/9

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N2 - Purpose: To describe the characteristics at presentation and the outcome of elderly patients (≥70 years old) with HCC, a retrospective analysis using a CLIP database was performed. Patients and methods: The database included 650 patients. χ2-test, logistic and Cox model were applied. Results: Baseline characteristics and stage were similarly among elderly (n = 158) and non-elderly (n = 492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p <0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival. Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.

AB - Purpose: To describe the characteristics at presentation and the outcome of elderly patients (≥70 years old) with HCC, a retrospective analysis using a CLIP database was performed. Patients and methods: The database included 650 patients. χ2-test, logistic and Cox model were applied. Results: Baseline characteristics and stage were similarly among elderly (n = 158) and non-elderly (n = 492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p <0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival. Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.

KW - CLIP score

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KW - Hepatocellular carcinoma

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