Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)

Sandro Pignata, Ciro Gallo, Bruno Daniele, Silvana Elba, Antonio Giorgio, Gaetano Capuano, Luigi Elio Adinolfi, Ilario De Sio, Francesco Izzo, Fabio Farinati, Carlo Del Naja, Maria Stanzione, Fabiana Castiglione, Giampiero Marone, Oreste Cuomo, Martina Felder, Giovanni Battista Gaeta, Ermelinda De Maio, Massimo Di Maio, Giuseppe Signoriello & 1 others Francesco Perrone

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Purpose: To describe the characteristics at presentation and the outcome of elderly patients (≥70 years old) with HCC, a retrospective analysis using a CLIP database was performed. Patients and methods: The database included 650 patients. χ2-test, logistic and Cox model were applied. Results: Baseline characteristics and stage were similarly among elderly (n = 158) and non-elderly (n = 492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p <0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival. Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalCritical Reviews in Oncology/Hematology
Volume59
Issue number3
DOIs
Publication statusPublished - Sep 2006

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Liver Neoplasms
Hepatocellular Carcinoma
Databases
Survival
Proportional Hazards Models
Therapeutics
Logistic Models

Keywords

  • CLIP score
  • Elderly
  • Hepatocellular carcinoma
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP). / Pignata, Sandro; Gallo, Ciro; Daniele, Bruno; Elba, Silvana; Giorgio, Antonio; Capuano, Gaetano; Adinolfi, Luigi Elio; De Sio, Ilario; Izzo, Francesco; Farinati, Fabio; Naja, Carlo Del; Stanzione, Maria; Castiglione, Fabiana; Marone, Giampiero; Cuomo, Oreste; Felder, Martina; Gaeta, Giovanni Battista; Maio, Ermelinda De; Maio, Massimo Di; Signoriello, Giuseppe; Perrone, Francesco.

In: Critical Reviews in Oncology/Hematology, Vol. 59, No. 3, 09.2006, p. 243-249.

Research output: Contribution to journalArticle

Pignata, S, Gallo, C, Daniele, B, Elba, S, Giorgio, A, Capuano, G, Adinolfi, LE, De Sio, I, Izzo, F, Farinati, F, Naja, CD, Stanzione, M, Castiglione, F, Marone, G, Cuomo, O, Felder, M, Gaeta, GB, Maio, ED, Maio, MD, Signoriello, G & Perrone, F 2006, 'Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)', Critical Reviews in Oncology/Hematology, vol. 59, no. 3, pp. 243-249. https://doi.org/10.1016/j.critrevonc.2006.01.002
Pignata, Sandro ; Gallo, Ciro ; Daniele, Bruno ; Elba, Silvana ; Giorgio, Antonio ; Capuano, Gaetano ; Adinolfi, Luigi Elio ; De Sio, Ilario ; Izzo, Francesco ; Farinati, Fabio ; Naja, Carlo Del ; Stanzione, Maria ; Castiglione, Fabiana ; Marone, Giampiero ; Cuomo, Oreste ; Felder, Martina ; Gaeta, Giovanni Battista ; Maio, Ermelinda De ; Maio, Massimo Di ; Signoriello, Giuseppe ; Perrone, Francesco. / Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP). In: Critical Reviews in Oncology/Hematology. 2006 ; Vol. 59, No. 3. pp. 243-249.
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AU - Giorgio, Antonio

AU - Capuano, Gaetano

AU - Adinolfi, Luigi Elio

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AU - Cuomo, Oreste

AU - Felder, Martina

AU - Gaeta, Giovanni Battista

AU - Maio, Ermelinda De

AU - Maio, Massimo Di

AU - Signoriello, Giuseppe

AU - Perrone, Francesco

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N2 - Purpose: To describe the characteristics at presentation and the outcome of elderly patients (≥70 years old) with HCC, a retrospective analysis using a CLIP database was performed. Patients and methods: The database included 650 patients. χ2-test, logistic and Cox model were applied. Results: Baseline characteristics and stage were similarly among elderly (n = 158) and non-elderly (n = 492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p <0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival. Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.

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