Characteristics of a large population of patients with refractory epilepsy attending tertiary referral centers in Italy

Veriano Alexandre, Giuseppe Capovilla, Cinzia Fattore, Valentina Franco, Antonio Gambardella, Renzo Guerrini, Francesca La Briola, Marianna Ladogana, Eleonora Rosati, Luigi Maria Specchio, Salvatore Striano, Emilio Perucca

Research output: Contribution to journalArticlepeer-review

Abstract

The characteristics of 1,124 consecutive adults and children with refractory epilepsy attending 11 tertiary referral centers in Italy were investigated at enrollment into a prospective observational study. Among 933 adults (age 16-86 years), the most common syndromes were symptomatic (43.7%) and cryptogenic (39.0%) focal epilepsies, followed by idiopathic (8.1%) and cryptogenic/symptomatic generalized (6.2%) epilepsies. The most common syndrome among 191 children was symptomatic focal epilepsy (35.1%), followed by cryptogenic focal (18.8%), cryptogenic/symptomatic generalized (18.3%), undetermined whether focal or generalized (16.8%), and idiopathic generalized (7.3%). Primarily and secondarily generalized tonic-clonic seizures were reported in 27.8% of adults and 16.8% of children. The most commonly reported etiologies were mesial temporal sclerosis (8.0%) and disorders of cortical development (6.2%) in adults, and disorders of cortical development (14.7%) and nonprogressive encephalopathies (6.8%) in children. More than three-fourths of subjects in both age groups were on antiepileptic drug (AED) polytherapy.

Original languageEnglish
Pages (from-to)921-925
Number of pages5
JournalEpilepsia
Volume51
Issue number5
DOIs
Publication statusPublished - May 2010

Keywords

  • Clinical features
  • Drug resistance
  • Epidemiology
  • Epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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