Characteristics of contemporary patients with hypertension and coronary artery disease

Rhonda M. Cooper-DeHoff, Eileen M. Handberg, Jerome Cohen, Peter Kowey, Franz H. Messerli, Giuseppe Mancia, Jose L. Cangiano, Efrain Gaxiola, David Garcia-Barreto, Ann C. Hewkin, Carl J. Pepine

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Abstract

Background: Despite a high prevalence of hypertension in the population with CAD, there are limited data describing the clinical characteristics and treatments, as well as their interrelations in these patients. This is particularly true for black and Hispanic patients who have been underrepresented in randomized CAD trials. Hypothesis: There exist racial and ethnic differences that define the characteristics of patients with both coronary artery disease (CAD) and hypertension. Methods: This report describes the characteristics of Caucasian, Hispanic, and black patients enrolled in the International Verapamil SR/trandolapril Study (INVEST), a prospective trial undertaken exclusively in patients with CAD and hypertension. Results: In all, 10,925 Caucasian, 8,045 Hispanic, and 3,029 black patients are described. An abnormal angiogram or documented myocardial infarction was observed more frequently in Caucasian patients (73%), while angina pectoris was more prevalent in Hispanic patients (87%). Diabetes and left ventricular hypertrophy were most common in black patients (33 and 29%, respectively), while hypercholesterolemia and prior revascularization (coronary artery bypass graft or angioplasty) were most common in Caucasian patients (64 and 41%, respectively). More than 60% of Hispanic and black patients were women-a unique characteristic for randomized CAD trials. Comparing race/ethnic cohorts, there were significant differences for all characteristics. More than 80% of patients in all race/ethnic groups were receiving antihypertensive therapy; however, only fewer than 25% had controlled blood pressure according to guidelines from the sixth report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Conclusions: This high-risk population of hypertensive patients with CAD has been undertreated and does not have well-controlled BP. Race/ethnic differences were observed for clinical characteristics and medication use.

Original languageEnglish
Pages (from-to)571-576
Number of pages6
JournalClinical Cardiology
Volume27
Issue number10
Publication statusPublished - Oct 2004

Fingerprint

Coronary Artery Disease
Hypertension
Hispanic Americans
trandolapril
Angina Pectoris
Left Ventricular Hypertrophy
Verapamil
Hypercholesterolemia
Angioplasty
Ethnic Groups
Coronary Artery Bypass
Antihypertensive Agents
Population
Angiography
Therapeutics
Myocardial Infarction
Prospective Studies
Guidelines
Blood Pressure
Transplants

Keywords

  • Black
  • Blood pressure control
  • Comorbidity
  • Coronary artery disease
  • Hispanic
  • Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cooper-DeHoff, R. M., Handberg, E. M., Cohen, J., Kowey, P., Messerli, F. H., Mancia, G., ... Pepine, C. J. (2004). Characteristics of contemporary patients with hypertension and coronary artery disease. Clinical Cardiology, 27(10), 571-576.

Characteristics of contemporary patients with hypertension and coronary artery disease. / Cooper-DeHoff, Rhonda M.; Handberg, Eileen M.; Cohen, Jerome; Kowey, Peter; Messerli, Franz H.; Mancia, Giuseppe; Cangiano, Jose L.; Gaxiola, Efrain; Garcia-Barreto, David; Hewkin, Ann C.; Pepine, Carl J.

In: Clinical Cardiology, Vol. 27, No. 10, 10.2004, p. 571-576.

Research output: Contribution to journalArticle

Cooper-DeHoff, RM, Handberg, EM, Cohen, J, Kowey, P, Messerli, FH, Mancia, G, Cangiano, JL, Gaxiola, E, Garcia-Barreto, D, Hewkin, AC & Pepine, CJ 2004, 'Characteristics of contemporary patients with hypertension and coronary artery disease', Clinical Cardiology, vol. 27, no. 10, pp. 571-576.
Cooper-DeHoff RM, Handberg EM, Cohen J, Kowey P, Messerli FH, Mancia G et al. Characteristics of contemporary patients with hypertension and coronary artery disease. Clinical Cardiology. 2004 Oct;27(10):571-576.
Cooper-DeHoff, Rhonda M. ; Handberg, Eileen M. ; Cohen, Jerome ; Kowey, Peter ; Messerli, Franz H. ; Mancia, Giuseppe ; Cangiano, Jose L. ; Gaxiola, Efrain ; Garcia-Barreto, David ; Hewkin, Ann C. ; Pepine, Carl J. / Characteristics of contemporary patients with hypertension and coronary artery disease. In: Clinical Cardiology. 2004 ; Vol. 27, No. 10. pp. 571-576.
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abstract = "Background: Despite a high prevalence of hypertension in the population with CAD, there are limited data describing the clinical characteristics and treatments, as well as their interrelations in these patients. This is particularly true for black and Hispanic patients who have been underrepresented in randomized CAD trials. Hypothesis: There exist racial and ethnic differences that define the characteristics of patients with both coronary artery disease (CAD) and hypertension. Methods: This report describes the characteristics of Caucasian, Hispanic, and black patients enrolled in the International Verapamil SR/trandolapril Study (INVEST), a prospective trial undertaken exclusively in patients with CAD and hypertension. Results: In all, 10,925 Caucasian, 8,045 Hispanic, and 3,029 black patients are described. An abnormal angiogram or documented myocardial infarction was observed more frequently in Caucasian patients (73{\%}), while angina pectoris was more prevalent in Hispanic patients (87{\%}). Diabetes and left ventricular hypertrophy were most common in black patients (33 and 29{\%}, respectively), while hypercholesterolemia and prior revascularization (coronary artery bypass graft or angioplasty) were most common in Caucasian patients (64 and 41{\%}, respectively). More than 60{\%} of Hispanic and black patients were women-a unique characteristic for randomized CAD trials. Comparing race/ethnic cohorts, there were significant differences for all characteristics. More than 80{\%} of patients in all race/ethnic groups were receiving antihypertensive therapy; however, only fewer than 25{\%} had controlled blood pressure according to guidelines from the sixth report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Conclusions: This high-risk population of hypertensive patients with CAD has been undertreated and does not have well-controlled BP. Race/ethnic differences were observed for clinical characteristics and medication use.",
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AU - Mancia, Giuseppe

AU - Cangiano, Jose L.

AU - Gaxiola, Efrain

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N2 - Background: Despite a high prevalence of hypertension in the population with CAD, there are limited data describing the clinical characteristics and treatments, as well as their interrelations in these patients. This is particularly true for black and Hispanic patients who have been underrepresented in randomized CAD trials. Hypothesis: There exist racial and ethnic differences that define the characteristics of patients with both coronary artery disease (CAD) and hypertension. Methods: This report describes the characteristics of Caucasian, Hispanic, and black patients enrolled in the International Verapamil SR/trandolapril Study (INVEST), a prospective trial undertaken exclusively in patients with CAD and hypertension. Results: In all, 10,925 Caucasian, 8,045 Hispanic, and 3,029 black patients are described. An abnormal angiogram or documented myocardial infarction was observed more frequently in Caucasian patients (73%), while angina pectoris was more prevalent in Hispanic patients (87%). Diabetes and left ventricular hypertrophy were most common in black patients (33 and 29%, respectively), while hypercholesterolemia and prior revascularization (coronary artery bypass graft or angioplasty) were most common in Caucasian patients (64 and 41%, respectively). More than 60% of Hispanic and black patients were women-a unique characteristic for randomized CAD trials. Comparing race/ethnic cohorts, there were significant differences for all characteristics. More than 80% of patients in all race/ethnic groups were receiving antihypertensive therapy; however, only fewer than 25% had controlled blood pressure according to guidelines from the sixth report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Conclusions: This high-risk population of hypertensive patients with CAD has been undertreated and does not have well-controlled BP. Race/ethnic differences were observed for clinical characteristics and medication use.

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