Characteristics of false positive findings in CT Colonography CAD: A comparison of two fecal tagging regimens

Lia Morra, Silvia Delsanto, Silvano Agliozzo, Riccardo Baggio, Erika Belluccio, Loredana Correale, Dario Genova, Alberto Bert, Daniele Regge

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The successful application of Computer Aided Detection schemes to CT Colonography depends not only on their performances in terms of sensitivity and specificity, but also on the interaction with the radiologist, and thus ultimately on factors such as the nature of CAD prompts and the reading paradigm. Fecal tagging is emerging as a widely accepted technique for patient preparation, and patient-friendlier schemes are being proposed in an effort to increase compliance to screening programs; the interaction between CAD and FT regimens should likewise be taken into account. In this scenario, an analysis of the characteristics of CAD prompts is of paramount importance in order to guide further research, both from clinical and technical viewpoints. The CAD scheme analyzed in this paper is essentially composed of five steps: electronic cleansing, colon surface extraction, polyp candidate segmentation, pre-filtering of residual tagged stool and classification of the generated candidates in true polyps vs. false alarms. False positives were divided into six categories: untagged and tagged solid stool, haustral folds, extra-colonic candidates, ileocecal valve and cleansing artifacts. A full cathartic preparation was compared with a semi-cathartic regimen with sameday fecal tagging, which is characterized by higher patient acceptance but also higher inhomogeneity. The distribution of false positives at segmentation reflects the quality of preparation, as more inhomogeneous tagging results in a higher number of untagged solid stool and cleansing artifacts.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Publication statusPublished - 2009
EventMedical Imaging 2009: Computer-Aided Diagnosis - Lake Buena Vista, FL, United States
Duration: Feb 10 2009Feb 12 2009


OtherMedical Imaging 2009: Computer-Aided Diagnosis
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • CAD
  • Cleansing
  • CT colonography
  • Digital stool subtraction
  • False positives
  • Oral contrast
  • Sameday fecal tagging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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